Lobular neoplasia. Long term risk of breast cancer and relation to other factors.

Background: Lobular neoplasia (LN), also known as lobular carcinoma in situ, is an incidental histologic finding in tissue removed at breast surgery. Patients with LN are known to be predisposed to develop invasive or intraductal carcinoma (CA). This study investigates factors that influence the cancer risk in LN patients.

Complex colon duplication mimicking an obstructed, non-functioning kidney in a newborn with imperforate anus and spinal dysraphism.

Gastrointestinal (GI) duplications contain tissue resembling several portions of the GI tract and are associated with vertebral and genitourinary (GU) abnormalities [1-4]. We report a newborn with low, imperforate anus and lumbosacral dysraphism, who presented with a large cystic mass in the left renal fossa and pelvis. The flank mass (felt initially to be a dysplastic kidney and ureter) proved to be a complex GI duplication with histologic evidence of gastric, small bowel, and colonic mucosa, as well as respiratory epithelium and pancreatic tissue.

Reproducibility and validity of pathologic classifications of benign breast disease and implications for clinical applications.

Background: Research studies on the relationship between benign breast diseases and cancer risk typically identify certain conditions as risk factors, and others as carrying no prognostic significance. This study addresses several issues concerning the relevance of such research results for advising individual patients in a clinical setting.

Methods: Data were obtained as part of a "blinded" retrospective pathology review of benign breast biopsies.

Prognostic significance of benign proliferative breast disease.

Background: Recent studies concerning an association between benign breast diseases and risk of subsequent breast cancer have focused on benign proliferative lesions recognized in biopsy specimens. Some have implicated atypical hyperplasia as being associated with the greatest risk.

Methods: The histologic sections of specified benign breast lesions from 1799 women were reviewed and reclassified, using published criteria for proliferative disease.

The epidemiology of gross cystic disease of the breast confirmed by biopsy or by aspiration of cyst fluid.

This study concerns 3443 patients treated by 1 physician for benign breast conditions, with follow-up on 94% of the patients averaging 19 years. Over three quarters of these patients had gross cystic disease (GCD) of the breast confirmed by aspiration of cyst fluid or by biopsy. Diagnosis of GCD by microscopic pathology review alone is shown to have high error rates when compared with information in the operative report and the gross pathology report.