Publications by authors named "K H Mayo"
Article Synopsis
- - The study investigates how genistein can potentially treat Sjögren's syndrome (SS) by targeting the genistein-estrogen receptor alpha (ERα) complex, which regulates the X-inactive specific transcript (Xist) and impacts ferroptosis through acyl-CoA synthetase long-chain family member 4 (ACSL4) in salivary gland epithelial cells (SGECs).
- - Researchers used nondiabetic obese (NOD)/LtJ mice and treated SGECs with Interferon-γ to evaluate changes in symptoms like dry mouth and to examine pathological lesions and molecular mechanisms underlying SS.
- - Results showed that genistein reduced SS symptoms by increasing Xist expression and decreasing Acsl
Glucosyltransferase TeGSS from Thermosynechococcus elongatus produces an α-1,2-glucan.
Int J Biol Macromol
November 2024
Here, we enzymatically produced a novel α-1,2-glucan, glucosylsucrose, that has a chemical structure significantly different from that of other glucans. This structural difference suggests its potential to modulate new physiological activities compared to known glucans. The enzyme TeGSS catalyzes the synthesis of this α-1,2-glucan from sucrose and UDP-glucose (UDPG).
View Article and Find Full Text PDFRaffinose family oligosaccharides (RFOs) have diverse structures and exhibit various biological activities. When using RFOs as prebiotics, their structures need to be identified. If we first knew whether an RFO was classical or non-classical, structural identification would become much easier.
View Article and Find Full Text PDFGalectins are multifunctional effectors in cellular homeostasis and dysregulation. Oxidation of human galectin-1 (Gal-1) with its six sulfhydryls produces a disulfide-bridged oxidized form that lacks normal lectin activity yet gains new glycan-independent functionality. Nevertheless, the mechanistic details as to how Gal-1 oxidation occurs remain unclear.
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