Cargo-less Nanoparticles Prevent Bone Loss in Periodontitis and Peri-implantitis.

Periodontal and peri-implant diseases are a significant public health problem worldwide, resulting in the destruction of the supporting bone. These bone defects can cause esthetic problems, increased relapse rate, and eventually tooth loss. The etiology of periodontal disease involves an influx of innate immune cells (neutrophils and monocytes) and upregulation of local inflammatory cytokines in the gingiva.

Fast Screening Libraries of Plant Growth Promoting Rhizobacteria (PGPRs) for Insecticidal Activity.

Aims: Plant Growth Promoting Rhizobacteria (PGPR) are ubiquitous among soil bacteria and aid in many growth-related functions for plants. Recent biotechnological advancements involving PGPRs have led to a growing desire to explore and uncover combinatorial or dual use PGPRs. Our study aimed to discover novel insecticidal phenotypes amongst PGPR libraries.

The DosR regulon of and adaptation to hypoxia.

Like other tuberculous and nontuberculous mycobacterial pathogens of human lung such as and , is likely exposed to a variety of stressors during infection, including hypoxic conditions inside activated macrophages and in the avascular necrotic regions of granulomas. How survives hypoxic stress to establish a chronic infection is currently not well understood. Using RNA-sequencing, we here show that grown under progressive microaerophilic conditions activates more than 4-fold a subset of 16 genes, the expression of 13 of which is dependent on the two-component system regulator DosRS.

Needs assessment of surgical skills of interns: a qualitative study in metropolitan Melbourne, Australia.

Introduction: Upon graduation, newly qualified doctors are expected to manage complex and unwell patients, and adapt their prior learning to navigate an often-nuanced healthcare workplace environment. Surgical rotations can bring a unique set of learning curves and challenges to this already demanding transitional period. The aim of this study was to identify the training needs of medical students and early-career doctors in surgical skills, incorporating viewpoints from all stakeholder groups to provide a holistic insight into the provision of surgical education currently, and how it can be optimized to improve work preparedness.