Publications by authors named "K H M Kollmann"
Repurposing the prostaglandin analogue treprostinil and the calcium-sensing receptor modulator cinacalcet to revive cord blood as an alternate source of hematopoietic stem and progenitor cells for transplantation.
Front Pharmacol
January 2025
Objective: The expanding field of hematopoietic cell transplantation (HCT) for non-malignant diseases, including those amenable to gene therapy or gene editing, faces challenges due to limited donor availability and the toxicity associated with cell collection methods. Umbilical cord blood (CB) represents a readily accessible source of hematopoietic stem and progenitor cells (HSPCs); however, the cell dose obtainable from a single cord blood unit is frequently insufficient. This limitation can be addressed by enhancing the potency of HSPCs, specifically their capacity to reconstitute hematopoiesis.
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- Post-transcriptional mechanisms play a vital role in maintaining progenitor cell identity and can be disrupted in cancer, particularly in acute myeloid leukemia (AML).
- Researchers used CRISPR screens to discover that regulators of P-bodies, which are cellular structures involved in RNA processing, are essential for the development and upkeep of AML.
- The study shows that while P-body loss minimally affects normal blood cell production, it significantly alters the behavior of leukemia cells by releasing tumor suppressor mRNAs, leading to changes in gene expression and potential new treatment strategies for myeloid leukemia.
Article Synopsis
- Deregulated transcription factors (TFs) like MYC and JUNB are key players in the growth of multiple myeloma (MM) but their specific roles and interactions within tumor cells are not well understood.
- This study reveals that MYC and JUNB operate through separate transcriptional programs, showing that changes in one do not affect the other, highlighting their independent regulation in MM cells.
- Targeting both MYC and JUNB simultaneously with new therapeutic strategies improves the effectiveness of treatment and could lead to better outcomes for MM patients.
Hematopoietic stem cells (HSCs) are characterized by the ability to self-renew and to replenish the hematopoietic system. The cell-cycle kinase cyclin-dependent kinase 6 (CDK6) regulates transcription, whereby it has both kinase-dependent and kinase-independent functions. Herein, we describe the complex role of CDK6, balancing quiescence, proliferation, self-renewal, and differentiation in activated HSCs.
View Article and Find Full Text PDFBackground/aims: Trachomatous trichiasis (TT) is a severe consequence of chronic inflammation/conjunctival scarring resulting from trachoma, the leading infectious cause of blindness worldwide. Our prospective cohort study evaluated the effectiveness of refresher training (RT) for experienced surgeons (1-22 years) on the outcomes of upper lid (UL) TT surgery in rural Ethiopia.
Methods: Patients undergoing UL TT surgery in at least one eye by a participating surgeon were included.