Publications by authors named "K H Ling"
Huntington's disease (HD) is caused by a CAG repeat expansion in the HTT gene, leading to altered gene expression. However, the mechanisms leading to disrupted RNA processing in HD remain unclear. Here we identify TDP-43 and the N6-methyladenosine (m6A) writer protein METTL3 to be upstream regulators of exon skipping in multiple HD systems.
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- Down syndrome (DS) is linked to trisomy 21, leading to intellectual disabilities and increased oxidative stress, impacting neuronal health.
- REST is a key protein involved in regulating genes related to DS neuropathology, and this study explores lithium’s effects on restoring REST levels in DS neurons.
- Results indicated that lithium treatment restored nuclear REST levels and significantly reduced reactive oxygen species (ROS) in DS neurons, suggesting potential therapeutic benefits of lithium for improving neuronal function in Down syndrome.
Background And Purpose: The quantitative intra-arterial flow dynamics following percutaneous transluminal angioplasty and stenting (PTAS) for severe intracranial artery stenosis have never been investigated. We aimed to evaluate peritherapeutic intracranial artery flow dynamics following PTAS with quantitative magnetic resonance angiography (qMRA) to predict long-term stent patency.
Design: This is a prospective, single-center study.
An InSe/Ge heterojunction is fabricated via molecular beam epitaxy. The p-n junction device features a broadened photosensitive spectrum ranging from a visible (VIS) to short-wave infrared (SWIR) region (400-1700 nm). Notably, self-powered high responsivity of 0.
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