Publications by authors named "K H Humphries"
Systematic error, often referred to as bias is an inherent challenge in observational cardiovascular research, and has the potential to profoundly influence the design, conduct, and interpretation of study results. If not carefully considered and managed, bias can lead to spurious results, which can misinform clinical practice or public health initiatives and compromise patient outcomes. This methodological primer offers a concise introduction to the identification, evaluation, and mitigation of bias in observational cardiovascular research studies assessing the causal association of an exposure (or treatment) on an outcome.
View Article and Find Full Text PDFOvarian aging is characterized by declines in follicular reserve and the emergence of mitochondrial dysfunction, reactive oxygen species production, inflammation, and fibrosis, which eventually results in menopause. Menopause is associated with increased systemic aging and the development of numerous comorbidities; therefore, the attenuation of ovarian aging could also delay systemic aging processes in women. Recent work has established that the anti-diabetic drug Canagliflozin (Cana), a sodium-glucose transporter 2 inhibitor, elicits benefits on aging-related outcomes, likely through the modulation of nutrient-sensing pathways and metabolic homeostasis.
View Article and Find Full Text PDFBackground: For emergency department (ED) patients with cardiac chest pain, introduction of high-sensitivity troponin (hsTnT) pathways has been associated with reductions in length of stay of less than 1 h.
Methods: At two urban Canadian sites, we introduced hsTnT on January 26, 2016. While the prior diagnostic algorithm required troponin testing at 0 and 6 h, serial hsTnT serial testing was conducted at 0 and 3 h.
Article Synopsis
- The study investigates the best revascularization method for diabetic patients with multivessel disease who experience a non-ST-segment elevation myocardial infarction (NSTEMI), comparing coronary artery bypass grafting (CABG) and multivessel percutaneous coronary intervention (PCI).
- It involves a large cohort of over 11,000 patients and reveals that CABG is linked to lower all-cause mortality than PCI, particularly in patients deemed potentially ineligible for CABG after a surgical consultation.
- The results suggest that while CABG is generally more beneficial for these patients, the advantage is more pronounced when comparing CABG to a specific group of PCI patients who had a surgical consultation beforehand.
Long-term outcomes among out-of-hospital cardiac arrest survivors with reversible vs. non-reversible causes.
Eur Heart J Acute Cardiovasc Care
October 2024
Article Synopsis
- The study aimed to analyze long-term outcomes in survivors of out-of-hospital cardiac arrest (OHCA) based on the cause of the arrest, particularly focusing on reversible vs. non-reversible etiologies.
- Researchers examined data from the British Columbia Cardiac Arrest registry, categorizing patients by their OHCA cause and measuring outcomes like mortality and rehospitalization over three years.
- Results indicated that survivors with reversible ischemic causes had the best outcomes, while those with reversible non-ischemic causes experienced the worst outcomes, highlighting the importance of identifying the underlying cause of cardiac arrests.