Special Issue: Molecular Ecology, Physiology and Biochemistry of Insects 4.0.

Insects make up the largest number of species and individuals in the world [...

Citrate Supplementation Modulates Medium Viscosity and Poly-γ-Glutamic Acid Synthesis by Engineered 168.

The industrially attractive biopolymer poly-γ-glutamic acid (γ-PGA) is commonly produced by species of the genus by co-feeding different carbon- and nitrogen-sources. Recent studies have highlighted the pivotal role of co-metabolization of a rapidly degradable carbon source such as glycerol together with citrate for γ-PGA production, independently fueling biomass generation as well as tricarboxylic acid (TCA) cycle precursor supply. With this study, we report that the sole presence of citrate in the production medium greatly influences growth behavior, γ-PGA production, and the viscosity of microbial cultures during biopolymer synthesis.

European general practitioners' attitudes towards person-centred care and factors that influence its implementation in everyday practice: The protocol of the cross-sectional PACE GP/FP study in 24 European countries.

Background: Person-centred care (PCC) is a fundamental principle in general practice, emphasising practices tailored to individual patient preferences, needs, and values. Despite the importance of PCC, general practitioners (GPs) face obstacles in effectively implementing it, with associated factors remaining unclear.

Objectives: The PACE GP/FP study aims to explore GPs' attitudes towards PCC and the factors facilitating or hindering its implementation in daily practice across European countries.

Multi-parametric [F]PI-2620 tau PET/MRI for the phenotyping of different Alzheimer's disease variants.

Purpose: Heterogeneity in clinical phenotypes has led to the description of different phenotypes of Alzheimer's disease (AD). Besides the most frequent amnestic variant of AD (aAD), patients presenting with language deficits are diagnosed with logopenic variant primary progressive aphasia (lvPPA), whereas patients presenting with visual deficits are classified as posterior cortical atrophy (PCA).

Methods: This study set out to investigate the value of a multi-parametric [F]PI-2620 tau PET/MRI protocol to distinguish aAD, lvPPA and PCA to support clinical diagnosis in 32 patients.

Frequency and treatment of venous thromboembolic events in patients with space-occupying brain infarction and decompressive craniectomy.

Introduction: Venous thromboembolic events (VTEs) like deep vein thrombosis or pulmonary embolism are frequent complications in (neuro) critical ill patients. Anticoagulation for VTE after space-occupying brain infarction is a therapeutic dilemma. The aim of this retrospective study was to investigate the frequency of clinically apparent VTE in patients with acute ischaemic stroke (AIS) due to large vessel occlusion (LVO), its treatment, and the rate of complications.