[The blood pressure-regulating role of the renin-angiotensin system in essential hypertension before and after emotional stress].

The aim of the study was to prove the correlations between systolic and diastolic blood pressure (BP), heart rate (HR) and plasma renin activity (PRA) under mental arithmetic stress without and with beta-blockade. 22 male hypertensive patients (aged 19-39 years) were examined, divided into a group treated with d, 1-propranolol (Obsidan) and a control group receiving placebo. Under arithmetic stress the kinetics of systolic BP showed no differences even after beta-blockade.

[The antihypertensive effect of saralasin in rabbits with neurogenic interoreceptive hypertension].

The renal nerve activity plays an essential role in the stimulation of plasma renin activity (PRA), which may be involved in the pathomechanism of neurogenic hypertension after sino-aortic denervation (SAD). Therefore, studies were conducted on unanesthetized rabbits (10 animals; 3-4 kg) after bilateral carotid sinus denervation plus section of cervical aortic nerves and the patterns of blood pressure (BP), heart rate (HR), and PRA were measured after a single injection-dosis of Saralasin (i.v.