Public Health.

Background: Identifying people at high risk of dementia allows for timely intervention, potentially slowing cognitive decline and delaying the onset of dementia. We externally validated commonly used risk predictions model for Alzheimer's dementia in Black American and white older adults.

Method: The study included 2,130 participants with 1,159 Black American and 971 white participants without dementia at baseline from the Chicago Health and Aging Project (CHAP).

Public Health.

Background: Variability in blood pressure has been associated with cerebrovascular disease independently of the adverse effects of hypertension or average blood pressure. We investigated whether visit-to-visit blood pressure variability is associated with global cognition in older adults.

Method: This study included 4,783 individuals aged 65 and older participating in the Chicago Health and Aging Project, a biracial population-based study.

Public Health.

Background: Social determinants of health (SDOH) are critically important to reduce disparities in Alzheimer's disease (AD). Yet, we often focus on individual-level characteristics, excluding socio-environmental factors, when evaluating predictors of AD or developing interventions that target AD prevention. To address these gaps, we examine the association between the social vulnerability index (SVI) and cognitive decline in a bi-racial cohort of older adults.

Public Health.

Background: Plasma levels of phosphorylated tau (pTau-181), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) as biomarkers of brain pathology and neurodegeneration have been associated with cognition and Alzheimer's dementia. Whether a dietary intervention modifies these relationships by potentially promoting cognitive reserve is unknown. We conducted a posthoc analysis of the MIND trial to investigate whether dietary intervention modifies the association of longitudinal changes in pTau-181, NfL, and GFAP with cognition during 3 years of follow-up.

Public Health.

Background: Observational studies have shown a protective association between antioxidant nutrients and lower risk of Alzheimer's disease. Results from dietary intervention trials remain inconclusive. The effect of APOE-e4, the strongest risk factor for AD, on responsiveness to dietary interventions remains largely uninvestigated.