Optimal timing of anti-PD-1 antibody combined with chemotherapy administration in patients with NSCLC.

Background: Anti-programmed cell death 1 (PD-1) antibody combined with chemotherapy simultaneously is regarded as the standard treatment for patients with advanced non-small cell lung cancer (NSCLC) by current clinical guidelines. Different immune statuses induced by chemotherapy considerably affect the synergistic effects of the chemo-anti-PD-1 combination. Therefore, it is necessary to determine the optimal timing of combination treatment administration.

An iodine-driven muscle-mimicking self-resetting bilayer hydrogel actuator.

Hydrogels that can swell and deswell under the influence of opposing external stimuli have frequently been reported as muscle-mimicking materials. However, the mechanism of such materials is markedly dissimilar to that of natural muscles. Natural muscles contract when fueled by ATP and spontaneously relax once ATP is completely consumed.

Corporate digital transformation and carbon emission intensity: Empirical evidence from listed companies in China.

Digital transformation is crucial for sustainable development of enterprises and for addressing the conundrum of "efficiency and environment". Utilizing a dataset from A-share listed companies in China from 2007 to 2021, this paper investigates the direct impact, underlying mechanism and driving effect of enterprise digital transformation on carbon emission intensity. The findings reveal that: (1) At this stage, digital transformation in listed companies effectively reduces their carbon intensity, but the relationship between the two is not linear; instead, it exhibits a U-shaped trajectory, initially decreasing then increasing.

Electrochemical detection of extracellular vesicles for early diagnosis: a focus on disease biomarker analysis.

This review article presents a detailed examination of the integral role that electrochemical detection of extracellular vesicles (EVs) plays, particularly focusing on the potential application for early disease diagnostics through EVs biomarker analysis. Through an exploration of the benefits and challenges presented by electrochemical detection vetted for protein, lipid, and nucleic acid biomarker analysis, we underscore the significance of these techniques. Evidence from recent studies renders this detection modality imperative in identifying diverse biomarkers from EVs, leading to early diagnosis of diseases such as cancer and neurodegenerative disorders.

Inhibition of Pyroptosis by Hydroxychloroquine as a Neuroprotective Strategy in Ischemic Stroke.

Hydroxychloroquine (HCQ), a well-known antimalarial and anti-inflammatory drug, has demonstrated potential neuroprotective effects in ischemic stroke by inhibiting pyroptosis, a programmed cell death associated with inflammation. This study investigates the impact of HCQ on ischemic stroke pathology using both in vivo and in vitro models. In vivo, C57BL/6 mice subjected to middle cerebral artery occlusion (MCAO) were treated with HCQ.