Publications by authors named "K Gundogan"
Purpose: Gastrointestinal (GI) dysfunction is common in critically ill patients and associated with poor outcomes. There is a lack of standardised methods for daily monitoring of GI function. COSMOGI aimed to develop a Core Outcome Set (COS) for daily monitoring of GI function to improve consistency and comparability in future studies in critically ill patients.
View Article and Find Full Text PDFArticle Synopsis
- Refeeding syndrome (RFS) is linked to serious electrolyte imbalances like hypophosphatemia, especially in hospitalized patients with inflammatory bowel disease (IBD), which can be worsened by malnutrition and severity of the disease.
- In a study of 50 IBD patients, 46% experienced hypophosphatemia during the first week of hospitalization, with significant correlations found between low phosphate levels and both potassium concentrations and disease severity.
- Factors such as malnutrition, the use of parenteral nutrition, and severe IBD were identified as significant predictors for developing hypophosphatemia in these patients, highlighting the need for careful monitoring and management.
Article Synopsis
- Acute ischemic stroke (AIS) is a serious complication in COVID-19 patients, with a study showing it occurred in 2.31% of hospitalized patients, primarily affecting older individuals with existing health issues.
- The study analyzed 693 COVID-19 patients from April 2020 to February 2021, revealing that many AIS cases arose within the first 24 hours, led by total anterior circulation infarction and cardioembolic causes.
- Patients with AIS had a higher prevalence of hypertension and heart disease, with a significant mortality rate, highlighting the need for awareness and monitoring for stroke risks in COVID-19 cases, particularly in older adults.
Background And Aims: The inconsistent data on thiamine status in obese subjects necessitates an examination of genes associated with intestinal absorption of thiamine. We aimed to reveal thiamine status in obese subjects and examine the expression of SLC19A2/3 genes encoding thiamine transporters and Sp1 transcription factor.
Methods And Results: Thirty-five adult obese subjects and 11 healthy controls were included in this cross-sectional study.
Article Synopsis
- Thiamine (Vitamin B1) plays a crucial role in energy metabolism, but its impact on overall metabolism during critical illness remains unexplored.
- The study analyzed the connection between whole blood thiamine pyrophosphate (TPP) levels and various plasma metabolites in critically ill patients, using advanced metabolomics techniques.
- Findings indicated that thiamine status is linked to multiple key metabolic pathways related to energy, carbohydrates, amino acids, and lipids in critically ill adults.