Semax prevents learning and memory inhibition by heavy metals.

Separate and joint effect of Semax, ascorbic acid, lead diacetate, and ammonium molybdate on avoidance conditioning in rats was studied. It was established that the heavy metal salts inhibited the avoidance response, and the peptide counteracted this inhibition as strongly as ascorbic acid or to a comparable degree. These findings confirm the antioxidant properties of Semax.

Poly(2-hydroxyethyl methacrylate) emboli with increased haemostatic effect for correction of haemorrhage of complex origin in endovascular surgery of children.

Poly(2-hydroxyethyl methacrylate) (PHEMA) embolization particles with enhanced haemostatic properties were prepared by bulk or suspension polymerisation of 2-hydroxyethyl methacrylate (HEMA) followed by particle soaking in ethamsylate solution. The particles accelerated thrombus formation as evidenced by blood analysis of rabbits with implanted emboli. Usefulness of both spherical and cylindrical PHEMA particles with enhanced haemostatic effect was demonstrated on the embolization of arterial anastomosis, fistulas of the lower extremity and abdominal cavity, haemangioma and arteriovenous malformation of the head of several children.

Poly(HEMA)--based embolic material in endovascular surgery of liver.

Physico-chemical and medico-biological methods, including hematology and cytology, were used in an evaluation of properties of poly(2-hydroxyethyl methacrylate) (poly(HEMA))-based embolic material indicated in the occlusion of branches of hepatic artery of patients with focal alterations of the liver. The elastographic method helped in predicting mechanical properties of the hydrogel material. Poly(HEMA) was mechanically stable for endovascular applications, exhibited no significant loss in elasticity and possessed consistency resembling the soft tissue of the organism.

Targeted chemoembolization of tumors with poly(2-hydroxyethyl methacrylate) particles.

Thirty-four patients suffering from various kinds of tumors, including metastasis, were treated by selective embolization with both spherical and cylindrical poly(2-hydroxyethyl methacrylate) [poly(HEMA)] particles and topical chemotherapy. Treatment of a patient with carcinoid metastases in the liver is discussed. Immediately after embolization, 5-fluorouracil, and later, doxorubicin and Lipiodol, were selectively infused into the tumorous tissue for approximately 1 week.