Publications by authors named "K Gulyas"
Some studies have used physical techniques for the assessment of bone structure and composition. However, very few studies applied multiple techniques, such as those described below, at the same time. The aim of our study was to determine the chemical and mineralogical/organic composition of bovine tibial bone samples using geophysical/geochemical reference techniques.
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- - Halogenation is a key technique used to modify lead compounds, enhancing their lipophilicity for better membrane permeability and bioavailability.
- - In this study, 19.9% of organohalogen compounds showed increased water solubility compared to their non-halogenated versions, with iodination being the most effective.
- - The presence of groups like amino, hydroxyl, and carboxyl in organohalogens boosts their solubility, while a trifluoromethyl group decreases it; increased polarity and polarizability from halogenation contribute to these changes.
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- This study investigates how tofacitinib, a JAK inhibitor, impacts metabolic changes associated with rheumatoid arthritis (RA) over one year, focusing on arginine and methionine levels and their connection to inflammation and cardiovascular health.
- Thirty RA patients were monitored for inflammatory markers, vascular function, and various amino acid levels before and after treatment, revealing significant decreases in inflammatory markers but no major changes in vascular function.
- After 12 months, higher doses of tofacitinib increased certain amino acids like L-arginine and methionine, with mixed correlations noted between these amino acids and inflammation, but no overall improvement in vascular function metrics was observed.
Cardiovascular (CV) disease and osteoporosis (OP) have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Bone and vascular biomarkers and parameters along with the effect of 1-year anti-TNF therapy on these markers were assessed in order to determine correlations between vascular pathophysiology and bone metabolism in RA and AS. Thirty-six patients treated with etanercept or certolizumab pegol and 17 AS patients treated with ETN were included in a 12-month follow-up study.
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