The Southern Center for Maternal Health Equity (SCMHE): a multisector multifaceted community-based approach to reduce disparities in maternal morbidity and mortality in the Gulf South.

Introduction: The maternal mortality crisis in the United States disproportionately affects women who are Black, especially those living in the Gulf South. These disparities result from a confluence of healthcare, policy, and social factors that systematically place Black women at greater risk of maternal morbidities and mortality. This study protocol describes the Southern Center for Maternal Health Equity (SCMHE), a research center funded by the National Institutes of Health in 2023 to reduce preventable causes of maternal morbidity and mortality while improving health equity.

Educational intervention in first aid for early childhood education professional: a quasi-experimental study.

Objective: To evaluate the effect of a first aid educational intervention on the aptitude, knowledge, and practices of professionals in early childhood education.

Method: Quasi-experimental study of the pre and post-test type carried out in the brazilian municipality of Três Lagoas, MS. It was developed in three stages: 1) application of an online instrument to assess aptitude, knowledge, and practices about situations that require first aid; 2) educational intervention, with four theoretical meetings online and a face-to-face meeting with practical training; 3) reapplying the questionnaire.

Clinical performance of an ormocer-based single-shade resin composite for the restoration of non-carious cervical lesions: 18-month randomized clinical trial.

Objective: This double-blind, split-mouth, randomized equivalence clinical trial aimed to evaluate the 18-month clinical performance of an ormocer-based single-shade resin composite compared with an ormocer-based multi-shade resin composite in non-carious cervical lesions (NCCLs).

Methods: One hundred and twenty restorations were performed on NCCLs with two restorative materials (n = 60): Admira Fusion X-tra resin composite (ormocer-based single-shade), and Admira Fusion resin composite (ormocer-based multi-shade). After rubber dam isolation, a universal adhesive was applied in the selective enamel etching strategy.

Prediction based on machine learning of tooth sensitivity for in-office dental bleaching.

Objective: To develop a supervised machine learning model to predict the occurrence and intensity of tooth sensitivity (TS) in patients undergoing in-office dental bleaching testing various algorithm models.

Materials And Methods: Retrospective data from 458 patients were analyzed, including variables such as the occurrence and intensity of TS, basal tooth color, bleaching material characteristics (concentration and pH), intervention details (number and duration of applications), and patient age. Classification and regression models were evaluated using 5-fold cross-validation and assessed based on various performance parameters.

FRET Probes for Detection of Both Active and Inactive Zika Virus Protease.

Proteases are a privileged class of enzymes due to their catalysis of an irreversible post translational modification, namely cleavage of substrate proteins. Protease activity is essential for human pathways including inflammation, blood clotting, and apoptosis. Proteases are also essential for the propagation of many viruses due to their role in cleavage of the viral polyprotein.