Publications by authors named "K Growkova"
Article Synopsis
- CDKs play a crucial role in cell division and have led to the development of small-molecule CDK inhibitors as potential cancer treatments, though their specific mechanisms in different tumors are not fully understood.
- This study reveals a connection between CDK activity and the overexpression of the MDM4 oncogene in cancer cells, suggesting that MDM4 could be the main target of CDK inhibitors in the p53 pathway, rather than MDM2.
- The findings indicate that CDK9 activity is vital for keeping high levels of MDM4, and CDK9 inhibitors might help restore the tumor suppressor function of p53 in cancers with MDM4 overexpression.
The reason why a few myeloma cells egress from the bone marrow (BM) into peripheral blood (PB) remains unknown. Here, we investigated molecular hallmarks of circulating tumor cells (CTCs) to identify the events leading to myeloma trafficking into the bloodstream. After using next-generation flow to isolate matched CTCs and BM tumor cells from 32 patients, we found high correlation in gene expression at single-cell and bulk levels (r ≥ 0.
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