Publications by authors named "K Grivcheva Stardelova"
Introduction: Vidofludimus calcium (VidoCa) is a dihydroorotate dehydrogenase inhibitor that demonstrated efficacy in immune-related diseases. This study assessed the safety and efficacy of VidoCa in patients with active ulcerative colitis (UC).
Methods: This placebo-controlled, phase 2 trial randomized adults with moderate-to-severe UC to receive once-daily VidoCa (10, 30, or 45 mg) or placebo for 10 weeks (induction); patients with symptomatic remission were rerandomized to VidoCa 10, 30 mg, or placebo once daily for an additional 40 weeks (maintenance).
Evaluation of the Effects of Gastro Protect as an Alternative Medicine on Gastritis and Other Gastrointestinal Symptoms.
Pril (Makedon Akad Nauk Umet Odd Med Nauki)
March 2024
Introduction: The use of herbal medicine as a part of the Complementary and Alternative Medicine is increasing worldwide. Herbal remedies are used to better different conditions including gastritis.
Material And Methods: We conducted a prospective randomized control clinical trial on a total sample of 72 patients with gastritis in order to examine the effects of the commercial herbal product Gastro Protect.
Comorbid Conditions in a Cohort of Inpatients with SARS-CoV-2 and their Association with In-Hospital Mortality During the Early Phases of the Pandemic.
Pril (Makedon Akad Nauk Umet Odd Med Nauki)
December 2023
: Studies determined that age and associated comorbidities are associated with worse outcomes for COVID-19 patients. The aim of the present study is to examine previous electronic health records of SARS-CoV-2 patients to identify which chronic conditions are associated with in-hospital mortality in a nationally representative sample. : The actual study is a cross-sectional analysis of SARS-CoV-2 infected patients who were treated in repurposed hospitals.
View Article and Find Full Text PDFBiologic Therapy in Inflammatory Bowel Disease - Results from a Single Tertiary Care Center in North Macedonia.
Pril (Makedon Akad Nauk Umet Odd Med Nauki)
July 2023
Article Synopsis
- Medical therapies for Inflammatory Bowel Disease (IBD) include both conventional options (like steroids and immunomodulators) and newer biologic treatments (such as TNF-alpha inhibitors and interleukin inhibitors).
- Until 2019, biologic medications were not covered by North Macedonia's public health insurance, limiting their use among IBD patients.
- A study conducted by the University Clinic of Gastroenterology and Hepatology in Skopje evaluates the effects of anti-TNF-alpha therapy on IBD patients who previously did not respond adequately to traditional treatments, now made more accessible since the introduction of insurance coverage.
The Value of Injection Therapy with Botulinum Toxin in Pain Treatment of Primary Chronic Anal Fissures Compared to Anal Dilation, and Local Nifedipine in Combination with Lidocaine.
Pril (Makedon Akad Nauk Umet Odd Med Nauki)
July 2023
: Anal fissure is a longitudinal tear of the mucosa of the anal canal extending from the outer anal orifice in the direction of the dentate line of the inner anal opening. Fissures are divided into primary and secondary, and acute or chronic. Besides minimal rectal bleeding, itching and soiling, primary chronic anal fissures (PCAF) manifest with anal pain as theirs main determinant.
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