Small-Molecule-Directed Endogenous Regeneration of Visual Function in a Mammalian Retinal Degeneration Model.

Degenerative retinal diseases associated with photoreceptor loss are a leading cause of visual impairment worldwide, with limited treatment options. Phenotypic profiling coupled with medicinal chemistry were used to develop a small molecule with proliferative effects on retinal stem/progenitor cells, as assessed in vitro in a neurosphere assay and in vivo by measuring Msx1-positive ciliary body cell proliferation. The compound was identified as having kinase inhibitory activity and was subjected to cellular pathway analysis in non-retinal human primary cell systems.

Hemispherically asymmetric Hadley cell response to CO removal.

A poleward shift of the Hadley cell (HC) edge in a warming climate, which contributes to the expansion of drought-prone subtropical regions, has been widely documented. The question addressed here is whether this shift is reversible with CO removal. By conducting large-ensemble experiments where CO concentrations are systematically increased and then decreased to the present-day level, we show that the poleward-shifted HC edge in a warming climate does not return to its present-day state when CO concentrations are reduced.

Activation of adult mammalian retinal stem cells in vivo via antagonism of BMP and sFRP2.

Background: The adult mammalian retina does not have the capacity to regenerate cells lost due to damage or disease. Therefore, retinal injuries and blinding diseases result in irreversible vision loss. However, retinal stem cells (RSCs), which participate in retinogenesis during development, persist in a quiescent state in the ciliary epithelium (CE) of the adult mammalian eye.

The winding path towards symbiotic autonomous systems.

Over the next 10 years, we are likely to see the convergence of two independent evolutionary paths: one leading to an augmentation of machine capabilities; the other with the augmentation of human capabilities. This convergence will not happen at a specific point in time; instead, it will be the result of progressive overlapping, to the point that it might be difficult to identify a defining moment. The following decade will likely be quite different from the present one.