Publications by authors named "K Grikscheit"
Article Synopsis
- The Omicron variant of SARS-CoV-2 has evolved to produce sublineages that can evade neutralizing antibodies differently, particularly affecting the immune response from mRNA vaccines.
- Breakthrough infections from the Omicron BA.4/BA.5 variant boost neutralization for some sublineages like BA.4.6 and BF.7 but not for others like BA.2.75.2 and XBB.
- Despite concerns about B cell immunity failure against certain sublineages, T cell immunity remains strong and effective, potentially helping to prevent severe COVID-19 outcomes even in the face of these emerging variants.
Article Synopsis
- The study aimed to evaluate olfactory dysfunction (OD) in both SARS-CoV-2 positive and negative patients to see if it could help identify COVID-19 infections early.
- Results showed that OD was present in 65.6% of COVID-19 positive patients and was more common in males and those with certain health conditions, with a notable increase in cases linked to the Delta variant compared to Omicron.
- Despite these findings, the sensitivity (69%) and specificity (64%) of OD as a diagnostic tool for identifying COVID-19 were deemed insufficient for it to be used routinely in clinical settings.
The ancestral SARS-CoV-2 strain that initiated the Covid-19 pandemic at the end of 2019 has rapidly mutated into multiple variants of concern with variable pathogenicity and increasing immune escape strategies. However, differences in host cellular antiviral responses upon infection with SARS-CoV-2 variants remain elusive. Leveraging whole-cell proteomics, we determined host signaling pathways that are differentially modulated upon infection with the clinical isolates of the ancestral SARS-CoV-2 B.
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- This study looks at heterologous (mixing vaccine types) versus homologous (same type) COVID-19 vaccination regimens, evaluating their side effects (reactogenicity) and effectiveness (immunogenicity).* -
- Heterologous vaccines showed lower side effects and better neutralizing response against variants like Delta compared to homologous mRNA vaccines, but both types showed waning immunity over time.* -
- After a third mRNA dose, most participants had strong neutralizing activity against Delta, but some participants still struggled with the Omicron variant, indicating that updated vaccines specifically for variants would be beneficial.*
The SARS-CoV-2 Omicron variant and its sublineages show pronounced viral escape from neutralizing antibodies elicited by vaccination or prior SARS-CoV-2 variant infection owing to over 30-amino acid alterations within the spike (S) glycoprotein. Breakthrough infection of vaccinated individuals with Omicron sublineages BA.1 and BA.
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