Publications by authors named "K Greffard"

Skeletal muscles are predominantly composed of long, multinucleated muscle fibers, classified according to their metabolic and contractile phenotype. The determination of fiber types is influenced by various factors (e.g.

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  • Lipid droplets (LD) are essential for storing triglycerides and play a significant role in regulating inflammation in cells, influenced by adipose triglyceride lipase (ATGL).
  • The study examined the effects of inhibiting ATGL and the genetic loss of ATGL in microglia on inflammatory responses, particularly focusing on cytokine expression and phagocytosis during LPS-induced inflammation.
  • Findings showed that ATGL inhibition led to reduced expression of pro-inflammatory cytokines (like IL-1β and IL-6), decreased inflammation-related behaviors, and altered lipid profiles, signifying ATGL's critical role in modulating neuroinflammatory responses.
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The properties of nanomedicines will influence how they can deliver drugs to patients reproducibly and effectively. For conventional pharmaceutical products, Chemistry, Manufacturing and Control (CMC) documents require monitoring stability and storage conditions. For nanomedicines, studying these important considerations is hindered by a lack of appropriate methods.

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Background: Statins are the leading lipid-lowering drugs, reducing blood cholesterol by controlling its synthesis. Side effects are linked to the use of statins, in particular statin-associated muscle symptoms (SAMS). Some data suggest that vitamin D supplementation could reduce SAMS.

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  • Very-long chain acyl-CoA dehydrogenase (VLCAD) is essential for breaking down long-chain fatty acids, and a deficiency can lead to unexplained heart rhythm issues in newborns.
  • Researchers tested VLCAD mice to examine how their heart's fat composition is altered, especially under high-fat diet conditions known to exacerbate symptoms in humans.
  • The study found significant lipid imbalances in VLCAD mice, including changes in fatty acid types and levels of specific molecules linked to heart rhythm regulation, suggesting that deficiencies in lipid metabolism may lead to calcium handling problems and stress in heart cells, contributing to arrhythmias.
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