[Increased urinary excretion of neopterin in patients with malignant tumors and with virus diseases (author's transl)].

Heightened urinary concentrations of neopterin were detected in patients with malignant tumors. The levels of neopterin were quantified by high performance liquid chromatography. The normal range for male individuals was 280 +/- 1,7 ng neopterin/mg creatinin, for women 340 +/- 116 ng neopterin/mg creatinin.

Enhanced urinary excretion of 7,8-dihydro-6-hydroxylumazine by mice bearing the Ehrlich ascites tumour.

A fluorescent urinary metabolite, excreted by mice carrying the Ehrlich ascites tumour (EAT), has been identified as 7,8-dihydro-6-hydroxylumazine. This finding agrees with other data which show that a disorder in pteridine metabolism is commonly associated with the presence of malignant growth.