Publications by authors named "K Govender"
An efficient microwave-assisted synthesis route for novel oxazolidinone analogues has been developed. The general synthesis of these compounds began with an L-proline-mediated three-component Mannich reaction between commercially available 3-fluoro-4-morpholinoaniline, aqueous formaldehyde and α-hydroxyacetone. This was followed by a one-step cyclisation to form the core structure of oxazolidinone antibiotics which was subsequently derivatized.
View Article and Find Full Text PDFBackground: Laboratory-based molecular assays return cycle threshold (Ct) values for each gene target. There is limited hyperlocal information describing the Ct, age and sex trends during the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) waves in South Africa.
Objectives: To analyse the demographic and Ct value trends of SARS-CoV-2 molecular assays from two South African hospitals.
Article Synopsis
- Scopolin and scopoletin are natural antioxidants from the coumarin class that have exhibited radical scavenging properties, but their mechanisms of action were not well understood until this study.
- Using Density Functional Theory (DFT) calculations, researchers found that scopoletin has a stronger antioxidant activity compared to scopolin, as indicated by its lower band gap energy and activation energy for radical scavenging.
- The study identified hydrogen atom transfer (HAT) as the primary mechanism for both compounds in scavenging radicals, with scopolin and scopoletin showing significant differences in bond dissociation energies that influence their antioxidant capacities.
Background: Health technology assessment uses explicit economic evaluation evidence to support health benefits package design. However, the limited availability of technical expertise, data, and methods has restricted the production of economic evaluation evidence in low- and middle-income countries. Zambia has initiated a roadmap to support its policy of reviewing and implementing its national benefits package.
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