Publications by authors named "K Gotthardt"
Article Synopsis
- Current COVID-19 vaccines effectively protect against severe illness but offer limited protection against infection itself.
- The study shows that XBB.1.5 mRNA boosters enhance serum neutralizing antibodies against various SARS-CoV-2 variants but do not significantly improve mucosal immune responses.
- This reveals a gap between systemic (peripheral) and mucosal immunity, suggesting the need for future vaccine developments aimed at boosting mucosal protection against respiratory viruses.
Studying people in real-life situations, such as making music in a vocal group, requires flexible and integrative measurement technology. Therefore, a digital browser-based survey instrument was developed for this study. It was designed to seamlessly introduce questions on participants' mobile devices through external control immediately after relevant events, aiming to achieve high accuracy in self-administered situational questions.
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- LRRK2 is a large protein with two important catalytic domains linked to both familial and sporadic forms of Parkinson's disease (PD), with mutations identified that increase its kinase activity.
- The study models the 3D structure of dimeric LRRK2 using various experimental techniques, revealing a compact and tightly organized architecture.
- It suggests an intramolecular mechanism for regulating LRRK2's kinase activity based on close interactions between different protein domains, providing a new structural framework for understanding its role in PD.
Small G-proteins of the ADP-ribosylation-factor-like (Arl) subfamily have been shown to be crucial to ciliogenesis and cilia maintenance. Active Arl3 is involved in targeting and releasing lipidated cargo proteins from their carriers PDE6δ and UNC119a/b to the cilium. However, the guanine nucleotide exchange factor (GEF) which activates Arl3 is unknown.
View Article and Find Full Text PDFWe have analyzed the distribution of mitochondrial contact site and cristae organizing system (MICOS) complex proteins and mitochondrial intermembrane space bridging complex (MIB) proteins over (sub)complexes and over species. The MICOS proteins are associated with the formation and maintenance of mitochondrial cristae. Indeed, the presence of MICOS genes in genomes correlates well with the presence of cristae: all cristae containing species have at least one MICOS gene and cristae-less species have none.
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