Clinical programming can limit access to binaural cues in children with bilateral cochlear implants.

Objective: In children with bilateral cochlear implants(CIs): 1) quantify cortical access and sensitivity to inter-aural level differences(ILDs); 2) determine if cortical ILD detection predicts ILD perception; and 3) assess demographic and clinical factors that could limit ILD access.

Methods: Cortical detection responses evoked by ILD changes were measured in 22/24 children with bilateral CIs(7 female) using their clinically programmed devices and in 8 children(3 female) with normal hearing. Behavioral lateralization(left vs right perception) to ILDs was also measured.

MIG-21 is a novel regulator of Wnt and Netrin signaling in gonad migration identified from published scRNA-seq data and functionally validated in .

Using a recently published scRNA-seq dataset of adult hermaphrodites, we identified a previously unknown regulator of the germ line stem cell niche (the distal tip cell, or DTC). The gene has the highest "marker score"-yet no known role-in the DTC. Using classical genetics techniques, RNAi knockdown, and live cell imaging, we discovered that integrates information from the Wnt and Netrin pathways to guide anteroposterior and dorsoventral DTC migration.

Effect of spesolimab on sustained disease control in patients with generalized pustular psoriasis: Post hoc analysis of the EFFISAYIL 2 study.

Background: Generalized pustular psoriasis (GPP) is a chronic inflammatory disease with an unpredictable disease course. Long-term treatment goals include sustained resolution of skin symptoms, prevention of new flares, and improvement in quality of life (QoL).

Objective: To compare the effect of the interleukin-36 receptor monoclonal antibody spesolimab 600 mg subcutaneous (SC) loading dose (LD) followed by 300 mg SC every 4 weeks (q4w) versus placebo on skin symptoms and QoL burden in patients with GPP.

Enhancing Robustness and Charge Transfer Kinetics of Sodium-Ion Batteries through Introduction of Anionic Anchoring Separators.

Ionic transport critically dictates the performance of the batteries. Here, we proposed an anion anchoring strategy for enhancing Na transport kinetics that was based on introducing a separator with a positive surface potential. Besides, we developed a nuclear magnetic resonance-assisted Hittorf approach to address the limitation of the traditional Bruce-Vincent approach itself in order to accurately quantify the migration dynamics of anions on the time scale.