Publications by authors named "K Gorbachev"
Article Synopsis
- Excitotoxicity and tau-mediated toxicities are key factors in neuronal death related to Alzheimer's disease (AD), with issues like glutamate levels being critical.
- *The main glutamate transporter, EAAT2 (GLT-1), is deficient in AD brains, leading to cell death from excitotoxicity, while tau protein buildup correlates with cognitive decline.
- *Research using mouse models revealed that GLT-1 deficiency affects pathways linked to neuronal survival, while tau mutations disrupt endocytic pathways and mitochondria, highlighting potential therapeutic targets.*
Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation.
Proc Natl Acad Sci U S A
August 2022
Tau protein aggregates are a major driver of neurodegeneration and behavioral impairments in tauopathies, including in Alzheimer's disease (AD). Apolipoprotein E4 (), the highest genetic risk factor for late-onset AD, has been shown to exacerbate tau hyperphosphorylation in mouse models. However, the exact mechanisms through which APOE4 induces tau hyperphosphorylation remains unknown.
View Article and Find Full Text PDFDysphagia and progressive swallowing problems due to motoneuron death is one of amyotrophic lateral sclerosis (ALS) symptoms. Malnutrition and body weight loss result in immunological disturbances, fatigability and increase risk of secondary complications in ALS patients, percutaneous endoscopic gastrostomy tube (PEG) placement representing a well-recognized method for malnutrition correction and potentially increasing life expectancy. However, despite nutritional correction, occasional rapid neurological deterioration may develop after PEG placement.
View Article and Find Full Text PDFAlzheimer's disease (AD) is the most frequent neurodegenerative disorder that commonly causes dementia in the elderly. Recent evidence indicates that network abnormalities, including hypersynchrony, altered oscillatory rhythmic activity, interneuron dysfunction, and synaptic depression, may be key mediators of cognitive decline in AD. In this review, we discuss characteristics of neuronal network excitability in AD, and the role of Aβ and tau in the induction of network hyperexcitability.
View Article and Find Full Text PDF[The Edinburgh Cognitive and Behavioral ALS Screen (ECAS): a Russian version.].
Zh Nevrol Psikhiatr Im S S Korsakova
May 2019
Aim: To translate into Russian and adapt the Edinburgh Cognitive and Behavioral ALS Screen (ECAS) for patients with amyotrophic lateral sclerosis (ALS).
Material And Methods: Medical care for ALS patients requires participation of a multidisciplinary team. More than one third of patients with ALS suffer from cognitive and behavioral disturbances, and it influences decisions of the team, patients and family.