Publications by authors named "K Gist"
Background: Continuous renal replacement therapy (CRRT) is the favored renal replacement therapy in critically ill patients. Predicting clinical outcomes for CRRT patients is difficult due to population heterogeneity, varying clinical practices, and limited sample sizes.
Objective: We aimed to predict survival to ICUs and hospital discharge in children and young adults receiving CRRT using machine learning (ML) techniques.
Article Synopsis
- This study examines the link between early postoperative levels of CCL14, a specific chemokine, and persistent severe acute kidney injury (AKI) in children who have undergone cardiac surgery.
- It was a retrospective analysis involving patients under 18 who had urine samples collected within the first day after surgery, focusing on those with and without persistent severe AKI, which was defined as lasting for 72 hours or more.
- The results showed that while persistent severe AKI occurred in a small percentage of patients and was associated with more complex surgeries, CCL14 levels did not differ significantly between those with and without AKI, suggesting it may not be a useful predictive marker.
Background: Outcomes for children with heart disease improved over the past decades. Quality improvement (QI) research in paediatric cardiac critical care is a key driver of improvement. The availability and variability of QI research across the field is unknown.
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- - A 7-year-old boy with mild asthma developed severe cardiogenic shock and required ECMO, highlighting a rare case of autoimmune adrenal insufficiency.
- - During his examination, the boy showed bronzing of his skin, prompting the administration of stress dose hydrocortisone for suspected adrenal issues.
- - After recovery and rehabilitation, the case emphasizes the importance of considering primary adrenal insufficiency in diagnosing circulatory shock based on physical and lab findings.
Background: Pediatric cardiac surgery-associated acute kidney injury (CS-AKI) is common with variable association with outcomes, possibly because transient serum creatinine (SCr) elevations are unrelated to kidney disease. Sub-phenotypes of CS-AKI with biomarker integration may provide prognostic enrichment. This study aims to determine if combining early postoperative urine neutrophil gelatinase-associated lipocalin (uNGAL) and SCr into sub-phenotypes strengthens associations with AKI and outcomes.
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