LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody-Drug Conjugates.

Progress in understanding tumor stromal biology has been constrained in part because cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell-type-specific protein markers. Using RNA expression profiling, we identified the membrane protein leucine-rich repeat containing 15 (LRRC15) as highly expressed in multiple solid tumor indications with limited normal tissue expression. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.

Using cognitive status to predict crash risk: blazing new trails?

Introduction: A computer-based version of an established neuropsychological paper-and-pencil assessment tool, the Trail-Making Test, was applied with approximately 700 drivers aged 70 years and older in offices of the Maryland Motor Vehicle Administration.

Method: This was a volunteer sample that received a small compensation for study participation, with an assurance that their license status would not be affected by the results. Analyses revealed that the study sample was representative of Maryland older drivers with respect to age and indices of prior driving safety.

The Maze Test: A significant predictor of older driver crash risk.

A study sponsored by the National Highway Traffic Safety Administration performed functional assessments on approximately 700 drivers age 70 and older who presented for license renewal in urban, suburban, and rural offices of the Maryland Motor Vehicle Administration. This volunteer sample received a small compensation for study participation, with an assurance that their license status would not be affected by the results. A comparison with all older drivers who visited the same sites on the same days indicated that the study sample was representative of Maryland older drivers with respect to age and prior driving safety indices.

'Low mileage bias' and related policy implications--a cautionary note.

This research examined a relationship asserted in recent literature in the field of traffic safety and injury prevention--that a significant indicator for elevated crash risk among older drivers, and potential trigger for individualized assessment at license renewal, is a low (<3000 km) annual driving distance. Sampling problems in earlier reports, in particular a reliance on self-report measures of both exposure and crash involvement, are highlighted. A pattern of misestimation for those who self-report an extremely low or extremely high number of miles driven is documented, that casts serious doubt upon the effect reported earlier.

Confirming human antibody responses to a therapeutic monoclonal antibody using a statistical approach.

Confirmatory assays for immunogenicity testing typically involve testing a sample in the presence or absence of excess drug. A decrease in assay signal in the presence of drug is taken to indicate the presence of anti-drug antibodies (ADAb) and the sample is confirmed positive. While there is widespread acceptance of the principle, there are currently no published guidelines for determining how much the signal should be reduced for a sample to be confirmed positive.