Structure-Function Relationship of a Novel MTX-like Peptide (MTX1) Isolated and Characterized from the Venom of the Scorpion .

Maurotoxin (MTX) is a 34-residue peptide from venom. It is reticulated by four disulfide bridges with a unique arrangement compared to other scorpion toxins that target potassium (K) channels. Structure-activity relationship studies have not been well performed for this toxin family.

Intracranial gossypiboma mimicking a recurrent glioma: A case report.

Cranial retained surgical sponges, known as "gossypiboma" or "textiloma", represent a rare but potentially severe complication following surgical procedures. While it is infrequent, it poses a significant risk, particularly in delicate surgical settings such as neurosurgery. The inadvertent retention of cotton balls or surgical gauzes may cause localized inflammation, infection, abscess, or neurologic sequelae.

Design and implementation of a scalable high-performance computing (HPC) cluster for omics data analysis: achievements, challenges and recommendations in LMICs.

Background: The advent of high-throughput technologies, including cutting-edge sequencing devices, has revolutionized biomedical data generation and processing. Nevertheless, big data applications require novel hardware and software for parallel computing and management to handle the ever-growing data size and analysis complexity. On-premise, high-performance computing (HPC) is increasingly used in biomedical research for big data stewardship.

Clinical and genetic spectrum of Ataxia Telangiectasia Tunisian patients: Bioinformatic analysis unveil mechanisms of ATM variants pathogenicity.

Ataxia Telangiectasia (AT) is a rare multisystemic neurodegenerative disease caused by biallelic mutations in the ATM gene. Few clinical studies on AT disease have been conducted in Tunisia, however, the mutational landscape is still undefined. Our aim is to determine the clinical and genetic spectrum of AT Tunisian patients and to explore the potential underlying mechanism of variant pathogenicity.