Publications by authors named "K Ghaffarzadegan"
Colorectal Cancer in North-Eastern Iran: a retrospective, comparative study of early-onset and late-onset cases based on data from the Iranian hereditary colorectal cancer registry.
BMC Cancer
January 2022
Article Synopsis
- The study investigates the rising incidence of colorectal cancer in patients under 50 by evaluating demographic and clinical characteristics in northeast Iran.
- It comprised a three-year retrospective analysis of 562 CRC cases, focusing on differences between early-onset (≤50 years) and late-onset (>50 years) cancer, including genetic risk factors like Lynch syndrome.
- Results indicated higher early-onset CRC rates in females (56%) compared to males (44%), with mean ages of 40.3 years for early-onset and 65.1 years for late-onset CRC, but the anatomical tumor location differences weren't statistically significant.
Background: The methylation of the CpG islands of the LINE-1 promoter is a tight control mechanism on the function of mobile elements. However, simultaneous quantification of promoter methylation and transcription of LINE-1 has not been performed in progressive stages of colorectal cancer. In addition, the insertion of mobile elements in the genome of advanced adenoma stage, a precancerous stage before colorectal carcinoma has not been emphasized.
View Article and Find Full Text PDFPurpose: Recently, 'solid tumor biopsies' have been challenged by the emergence of 'liquid biopsies', which are aimed at the isolation and detection of circulating cell-free tumor DNA (ctDNA) in body fluids. Here, we developed and optimized a method for selective capture of ctDNA on magnetic beads (SCC-MAG) for mutation detection in plasma of patients with colorectal cancer (CRC).
Methods: Blood and tissue samples from 28 CRC patients were included for the detection of KRAS mutations.
Background: Nonalcoholic fatty liver disease (NAFLD) exhibits a worldwide distribution and encompasses a wider range of hepatic abnormalities that can culminate in serious clinical outcomes. The growing incidence of NAFLD necessitates more efficient management strategies particularly in clinically severe obese patients. Weight reduction is the cornerstone of NAFLD treatment; therefore, bariatric surgery could be a therapeutic approach in selected obese patients afflicted with NAFLD and other cardiometabolic comorbidities.
View Article and Find Full Text PDFBackground: Lynch syndrome (LS) increases the risk of many types of cancer, mainly colorectal cancer (CRC). The purpose of this study was to assess the prevalence of mismatch repair (MMR) deficiency in patients under the age of 50 with advanced adenomatous polyps, aiming at an early diagnosis of LS.
Methods: This retrospective, cross-sectional study included eligible patients with advanced adenomas diagnosed ≤ 50 years of age registered between April 2014 and February 2017 at three pathology centers in Mashhad.