Publications by authors named "K Geraki"
Article Synopsis
- Previous research indicated that the MRI probe GdL1 can differentiate between healthy and cancerous prostate tissues based on zinc levels.
- Mice were given varying zinc diets for three weeks, and their prostate zinc secretion was analyzed using advanced imaging techniques.
- Results showed that healthy mice effectively regulated zinc levels, while cancerous mice struggled, suggesting that zinc supplements before imaging could improve prostate cancer detection accuracy.
Heterotopic ossification (HO) in tendons can lead to increased pain and poor tendon function. Although it is believed to share some characteristics with bone, the structural and elemental compositions of HO deposits have not been fully elucidated. This study utilizes a multimodal and multiscale approach for structural and elemental characterization of HO deposits in healing rat Achilles tendons at 3, 6, 12, 16, and 20 weeks post transection.
View Article and Find Full Text PDFIron dyshomeostasis and neuroinflammation, characteristic features of the aged brain, and exacerbated in neurodegenerative disease, may induce oxidative stress-mediated neurodegeneration. In this study, the effects of potential priming with mild systemic iron injections on subsequent lipopolysaccharide (LPS)-induced inflammation in adult C57Bl/6J mice were examined. After cognitive testing, regional brain tissues were dissected for iron (metal) measurements by total reflection X-ray fluorescence and synchrotron radiation X-Ray fluorescence-based elemental mapping; and iron regulatory, ferroptosis-related, and glia-specific protein analysis, and lipid peroxidation by western blotting.
View Article and Find Full Text PDFTwo events share the stage as main drivers of the Cretaceous-Paleogene mass extinction-Deccan Traps volcanism, and an asteroid impact recorded by the Chicxulub crater. We contribute to refining knowledge of the volcanic stressor by providing sulfur and fluorine budgets of Deccan lavas from the Western Ghats (India), which straddle the Cretaceous-Paleogene boundary. Volcanic fluorine budgets were variable (400 to 3000 parts per million) and probably sufficient to affect the environment, albeit only regionally.
View Article and Find Full Text PDFArticle Synopsis
- - Atherosclerosis is a serious disease that can lead to heart attacks and strokes, but diagnosing vulnerable plaques is difficult because current methods lack accuracy and specificity.
- - New technologies are being developed using customized nanoparticles for noninvasive imaging of atherosclerotic plaques, which can improve diagnosis and prediction of plaque rupture risk.
- - Our research focuses on comparing the imaging effectiveness of different nanoparticles, demonstrating that Gd (III)-doped amorphous calcium carbonate nanoparticles are promising for targeted imaging of atherosclerosis, particularly when functionalized with specific ligands for targeting calcifications and inflammation.