Publications by authors named "K George Varghese"

Background: Online digital materials are integral to patient education and health care outcomes in dermatology. Acanthosis nigricans (AN) is a common condition, often associated with underlying diseases such as insulin resistance. Patients frequently search the internet for information related to this cutaneous finding.

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Introduction: The quality of packed red blood cells (PRBC) is influenced by various factors such as the collection and processing method, storage conditions, type of bag materials used, anticoagulant properties, and donor characteristics. Studies have indicated that haemolysis in stored RBC bags is linked to male sex, older age, high haemoglobin count, and increased body mass index (BMI). The study's primary objective was to investigate whether a high BMI, as per Asian Pacific criteria among donors, is associated with an elevated haemolysis rate in stored RBC.

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Obstructive sleep apnea (OSA) is often a lifestyle disease associated with obesity, which is rapidly evolving as a major health concern with diverse multisystemic implications. To prevent and mitigate its adverse effects and reduce its burden on society, its aetiopathogeneses must be precisely understood. Numerous studies focusing on the range of diverse anatomic, functional, and lifestyle factors have already been carried out to determine the possible contributory roles of these factors in OSA.

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Article Synopsis
  • - The study investigates the integration of work coaches (WCs) and disability employment advisors (DEAs) into UK GP practices to improve access to employment support for individuals with disabilities and health issues.
  • - Data was collected through interviews with four GPs, WCs, and DEAs, revealing that while professionals recognize the benefits of collaboration and patient openness, they also face challenges in implementation due to resources and support.
  • - The findings suggest that embedding WCs and DEAs in GP practices has positive potential, but further exploration of patient perspectives and addressing additional challenges are necessary for successful service delivery.
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Article Synopsis
  • Mouse models with humanized ACE2 and TMPRSS2 genes were created to study how Th1 and Th2 immune responses affect SARS-CoV-2 infection.
  • Mice infected with the Delta variant required ACE2 for lung infection, while Omicron didn't, with Omicron causing more severe disease in specific mouse models.
  • The study suggests that the genetic background of the host influences the immune response and severity of SARS-CoV-2 infections, highlighting the need for more research on this variability.
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