Publications by authors named "K Gennermann"
Article Synopsis
- Celiac disease (CeD) is an autoimmune disorder triggered by gluten, leading to small intestine damage and an increased risk associated with infections like Influenza A.
- This study analyzed T-cell receptors (TCRs) from 56 CeD patients and 22 controls, focusing on how gluten-specific CD4 T-cells and gluten-triggered CD8 T-cells contribute to the immune response in CeD.
- Results showed that CD8 T-cell TCRs are significantly more prevalent in the intestinal tissues of CeD patients, particularly in severe cases, suggesting a potential link between these TCRs and the recognition of other antigens, including viral and microbial sources.
Availability of plant-specific enzyme kinetic data is scarce, limiting the predictive power of metabolic models and precluding identification of genetic factors of enzyme properties. Enzyme kinetic data are measured in vitro, often under non-physiological conditions, and conclusions elicited from modeling warrant caution. Here we estimate maximal in vivo catalytic rates for 168 plant enzymes, including photosystems I and II, cytochrome-b6f complex, ATP-citrate synthase, sucrose-phosphate synthase as well as enzymes from amino acid synthesis with previously undocumented enzyme kinetic data in BRENDA.
View Article and Find Full Text PDFMotivation: Actin filaments (AFs) are dynamic structures that substantially change their organization over time. The dynamic behavior and the relatively low signal-to-noise ratio during live-cell imaging have rendered the quantification of the actin organization a difficult task.
Results: We developed an automated image-based framework that extracts AFs from fluorescence microscopy images and represents them as networks, which are automatically analyzed to identify and compare biologically relevant features.