Publications by authors named "K Garming Legert"
Purpose: Benefits of prophylactic platelet (PLT) transfusion before dentoalveolar surgery are unclear. This study investigated the effect of prophylactic PLT transfusions on the incidence of postoperative bleeding (POB) in patients with thrombocytopenia and a PLT count ≤ 75*10/L.
Methods: The cohort in this retrospective study comprised 83 patients with thrombocytopenia ≤ 75*10/L who had undergone dentoalveolar surgery.
Morbidity and mortality among children, adolescents, and young adults with cancer over six decades: a Swedish population-based cohort study (the Rebuc study).
Lancet Reg Health Eur
July 2024
Article Synopsis
- The study investigates the long-term effects of cancer in children, adolescents, and young adults (CAYAs) in Sweden, revealing significant morbidity and mortality rates linked to socioeconomic factors.
- CAYAs were found to have significantly higher risks of developing subsequent cancers, cardiovascular diseases, and mortality compared to matched controls, with various demographic factors influencing these outcomes.
- The findings highlight the need for targeted research and interventions to address the socioeconomic disparities impacting the health and quality of life for young cancer survivors.
Single nucleotide polymorphisms conferring susceptibility to leukemia and oral mucositis: a multi-center pilot study of patients prior to conditioning therapy for hematopoietic cell transplant.
Support Care Cancer
March 2024
Purpose: Leukemias have been associated with oral manifestations, reflecting susceptibility to cancer therapy-induced oral mucositis. We sought to identify SNPs associated with both leukemia and oral mucositis (OM).
Methods: Whole exome sequencing was performed on leukemia and non-cancer blood disorder (ncBD) patients' saliva samples (N = 50) prior to conditioning therapy.
Introduction: Chronic graft-versus-host disease (cGVHD) is a debilitating side effect of allogeneic hematopoietic cell transplantation (HCT), affecting the quality of life of patients. We used whole exome sequencing to identify candidate SNPs and complete a multi-marker gene-level analysis using a cohort of cGVHD( +) (N = 16) and cGVHD( -) (N = 66) HCT patients.
Methods: Saliva samples were collected from HCT patients (N = 82) pre-conditioning in a multi-center study from March 2011 to May 2018.
The oral cavity commonly displays mucosal lichenoid lesions and salivary gland dysfunction, which are considered different chronic Graft-versus-Host Disease (cGVHD) pathophysiology's. However, diagnostics of salivary gland (sg-)cGVHD are limited. The objectives of the current study are to evaluate the minor salivary gland (MSG) histo-immunopathological profiles post allogenic hematopoietic cell transplantation based on sg-cGVHD criteria.
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