Improving Wheat Grain Yield Genomic Prediction Accuracy Using Historical Data.

Genomic selection (GS) is an essential tool to improve genetic gain in wheat breeding. This study aimed to enhance prediction accuracy (PA) for grain yield (GY) across various selection environments (SEs) using CIMMYT's (International Maize and Wheat Improvement Center) historical dataset. Ten years of GY data from six SEs were analyzed, with the populations of five years (2018-2023) as the validation population (VP) and earlier years (back to 2013-2014) as the training population (TP).

Synergism between TLR4 and B. infantis in the development of the premature intestine.

Background: Intestinal microbiota has a role in early life maturation including maturation of intestinal immune function. However, the interaction of the TLR4 with colonizing bacteria in intestinal development is incompletely understood.

Methods: An established human immature small intestinal cell line, human fetal intestinal organoids, and wild-type (WT) and TLR4 gene knockout (TLR4 ) neonatal mice were used to test the synergism between the innate immune receptor TLR4 and postbiotics from Bifidobacteria longum subsp.

Oral COVID-19 antiviral prescribing in Australian general practice - a retrospective observational study.

Background This study aimed to gain a comprehensive understanding of oral COVID-19 antiviral prescribing in Australian general practice. Methods The study was a retrospective observational cohort study. Routinely collected, de-identified, Australian general practice consultation and prescription data was used with permission from participating primary health networks, from 938 general practices between March 2022 and September 2023.

A National Survey of Caregiver Needs and Experiences When Attending the Emergency Department.

Objectives: Despite being a frequent entry point of care, it remains unknown if families' needs are being met across pediatric emergency departments (PEDs). Study objectives were to describe caregivers' perceived overall PED experience and needs and to what extent these needs were met.

Methods: This descriptive, cross-sectional survey with medical record review was conducted in 10 Canadian PEDs.

Associate Psychological Practitioners (APPs) in primary care: modelling the impact.

Background: The 'Associate Psychological Practitioner' (APP) is an innovative new role that expands the psychological workforce and addresses the rising demand for mental health services in England, yet the impact of this role on NHS workforce capacity has yet to be modelled.

Aim: We modelled the impact of the APP role in Primary Care in terms of additional capacity to provide mental health care and the impact on General Practitioner (GP) capacity within the sector.

Method: Workforce experts of the NHS Workforce Repository and Planning Tool (WRaPT) team used a modelling tool to determine future state scenarios of APPs working across all Primary Care Networks (PCNs) within a region and the associated change on the baseline workforce.