Publications by authors named "K Gamo"
Article Synopsis
- Stromal cells in breast cancer help regulate the spread of tumors and are influenced by the tumor cells themselves.
- The study focused on α-parvin, a protein linked to poor prognosis in various cancers, to see if it could be a therapeutic target by analyzing its expression in breast cancer tissues.
- Results showed that α-parvin levels were significantly higher in breast cancer tissues compared to normal ones and were positively correlated with cancer proliferation and disease classification, suggesting its potential as a diagnostic marker.
Diverse molecular species of sulfatide with differences in FA lengths, unsaturation degrees, and hydroxylation statuses are expressed in the kidneys. However, the physiological functions of specific sulfatide species in the kidneys are unclear. Here, we evaluated the distribution of specific sulfatide species in the kidneys and their physiological functions.
View Article and Find Full Text PDFPurpose: This study aimed to evaluate the efficacy of hand therapy after volar locking plate fixation of distal radius fractures in middle-aged to elderly women.
Methods: Fifty-seven patients diagnosed with distal radius fractures who had undergone volar plate fixation were enrolled in a prospective, randomized controlled trial. Patients were randomized into the hand therapy and independent exercise (IE) groups, in which they exercised independently under the surgeon's direction with and without hand therapy, respectively.
The accumulation of β-amyloid (Aβ) aggregates in the brain occurs early in the progression of Alzheimer's disease (AD), and non-fibrillar soluble Aβ oligomers are particularly neurotoxic. During binding to Aβ fibrils, curcumin, which can exist in an equilibrium state between its keto and enol tautomers, exists predominantly in the enol form, and binding activity of the keto form to Aβ fibrils is much weaker. Here we described the strong binding activity the keto form of curcumin derivative Shiga-Y51 shows for Aβ oligomers and its scant affinity for Aβ fibrils.
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- Protein knockdown using the auxin-inducible degron (AID) technology helps study protein functions in live cells by rapidly depleting proteins, allowing for immediate observation of phenotypic changes.
- The original AID system has issues, including unreliable protein degradation (leaky degradation) and a need for high auxin doses, complicating control over protein expression.
- The new AID version 2 (AID2) improves upon these problems by using a modified mutant and a lower concentration ligand, resulting in faster and more precise protein degradation across human cells, yeast, and even mice.