Carcinogenesis--a new point of view.

Presented article suggests the novel hypothesis of carcinogenesis, where the key moment for all types (biological, physical, chemical) of carcinogenesis has been discussed. For confirmation of the hypothesis thorough theoretical analysis of the mechanisms of malignant transformation of cells after influence of any type of carcinogens and results of experiments have been presented. Hypothesis highlights are formulated as follows: 1) Covalent bond disorders between S+-methionine and Fe3+ atoms in cytochrome; 2) Electron transport chain blockade with certain ligand after its penetration in cytochrome pocket with further formation of 6th coordination bond between ligand and Fe atom (in one case increase in mitochondrial pH precede-, and in other, it follows electron transport chain blockade in cytochromes); 3) Fe3+ reduction up to Fe2+ leading to blockade of aerobic glycolysis; 4) Decrease in enzyme (Е1-TDP, oxidases etc.

Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

Background: The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100,000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in maternal mortality, the key causes contributing to maternal death, and timing of maternal death with respect to delivery.

Methods: We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to analyse a database of data for 7065 site-years and estimate the number of maternal deaths from all causes in 188 countries between 1990 and 2013.

[Bacterial phagelysates and malignant tumor growth].

Anti-tumor preventive efficacy of E.coli phagelysate has been studied. Investigations were conducted on 2-3 months 48 male mice.

Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo.

Aim: The aim of the presented article was investigation of anticancer efficacy of hydroxyethylthiamine diphosphate (HTD) in vivo.

Materials And Methods: The study was carried out on 30 C57BL/6J mice subcutaneously transplanted with Ehrlich carcinoma. Animals were treated with intraperitoneal injections of the solution composed from pyruvic acid and thiamine bromide every other day during 10 days and thereafter, every day during 2 weeks.

The novel hypothesis of carcinogenesis and anti-cancer treatment perspectives - Hydroxyethylthiamine diphosphate.

In presented article, the novel hypothesis of carcinogenesis, and thorough discussion of some essential biochemical mechanisms which might be responsible for the malignant transformation of cells (bond disorders between Fe(3+) and S(+)-methionine in cytochrome; blockage of the last 3-d orbital of Fe by the certain ligand and formation of 6th coordinated bond leading to Fe(3+) reduction up to Fe(2+) and cessation of tissue respiration; increase in mitochondrial pH and further in cell, leading to decreased activity of most of enzymes (thiamine diphosphate, oxidases); formation of S-adenosyl-methionine with its further dissociation and production of adenosine and homocysteine; effects of homocysteine on DNA structures, homocysteine-induced dimethylation of certain nitrogen basis and their extrusion from strands of DNA leading to mutations and cellular atypism) has been suggested. Along with theoretical discussions, article provides results of preliminary investigations carried out on C57Bl/6J mice with Ehrlich carcinoma aimed to capture lipoic acid amide with Hydroxyethylthiamine diphosphate, and study effects of Hydroxyethylthiamine diphosphate against malignant transformation of cells. Experiments have shown inhibition of cancer growth in treated animals.