The HPV-TP53-MALAT1 Axis: Unravelling interactions in cervical cancer development.

Introduction: Cervical cancer, primarily driven by Human Papillomavirus (HPV) infection, stands as a substantial global health challenge. The TP53 gene's, Arg72Pro polymorphism has emerged as a noteworthy player in cervical cancer development, particularly among individuals harboring high-risk (HR) HPV types. Additionally, long non-coding RNAs (lncRNAs), exemplified by metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), exert critical roles in cancer biology.

[ANALYSIS OF THE USE OF ANTIBIOTIC THERAPY IN PREMATURE INFANTS, TAKING INTO ACCOUNT THE CHARACTERISTICS OF THE NEONATAL PERIOD].

This article presents the results of sensitivity/resistance of microbial strains isolated from three biotopes, in premature infants: mucous membranes of the respiratory tract, urinary system and colon after 72 hours after birth, as well as on the 14th and 30th day of life. During the study, total 677 strains of various microorganism species were isolated of which gram-positive flora - 386 microbial strains, almost 1.5 times predominated over gram-negative (291 strains) flora.

[THE MICROBIAL STRUCTURE OF THE MUCOUS MEMBRANE OF THE RESPIRATORY TRACT IN PREMATURE INFANTS].

This article presents the results of a microbiological study of microbial contamination of the respiratory tract mucosa of 124 premature newborns with different gestational age (24-28 and 29-36 weeks) who are in the critical medicine department of LTD "Imedis Clinica", Tbilisi. For the study, modern methods of qualitative and quantitative microbiological analysis were used, as well as the determination of the sensitivity/resistance of the isolated microorganisms to antibiotics using standard disks by the discdiffusion method and the serial dilution method on solid nutrient media, which were performed on newborns for the first 72 hours, on days 14 and 30. In the first 72 hours microbial colonization was established only in 20.

[ANTIBIOTIC SENSITIVITY/RESISTANCE OF MICROBIAL STRAINS ISOLATED IN TRAUMATOLOGICAL DEPARTMENT].

In this article, there are given data of study for antibiotic sensitivity/resistance of gram-positive and gram-negative representatives of different microbial species, isolated from patients after primary hip replacement and osteosynthesis of long bones, which had post operative infectious complications, and also isolated from samples of traumatology department environment. Identification of sensitivity/resistance to antibiotics was performed with use of two methods - disc diffusion and serial dilution on solid nutrient media. It was found, that gram-positive, as well as gram-negative microorganisms had high level of resistance to several penicillins and aminoglycosides.

[ANTIBIOTIC SENSITIVITY/RESISTANCY OF MICROBIAL STRAINS, ISOLATED FROM PUERPERAS, NEWBORNS AND SAMPLES OF MATERNITY WARD ENVIRONMENT].

In this article, there are given data of microorganisms sensitivity/resistancy investigation, to different groups of antibiotics. Microorganisms where isolated from puerperas, newborns and samples of maternity ward environment. Investigation was performed in L.