Publications by authors named "K G van Horn"
Insulin Delivery Pumps for Human Spaceflight: Steps Toward an Accessible Space Future.
Wilderness Environ Med
January 2025
Commercially available insulin pumps for treatment of diabetes mellitus are currently not qualified to operate in the space environment. This work rigorously tested the fluid delivery performance of a Tandem t:slim X2 insulin pump in both micro- and hypergravity during a parabolic microgravity research flight. The parabolic research flight environment serves as an analogue to the types of transient gravitational loadings experienced during human-led missions, which provides a foundation to expand testing to suborbital and orbital flights in addition to other extreme environmental tests for wilderness dependency.
View Article and Find Full Text PDFChanges in temperature and precipitation are already influencing US forests and that will continue in the future even as we mitigate climate change. Using spatiotemporally matched data for mean annual temperature (MAT) and mean annual precipitation (MAP), we used simulated annealing to estimate critical thresholds for changes in the growth and survival of roughly 150 tree species (153 spp. for growth, 159 spp.
View Article and Find Full Text PDFArticle Synopsis
- * Data was collected from a national sample of 4,091 young adults (18-34) and analyzed using logistic regression to explore the relationship between neighborhood racial/ethnic and economic segregation and smoking behavior.
- * Results revealed that residents in areas with higher concentrations of Hispanic/Latino and Black individuals had increased smoking risks, especially when compared to those in wealthier, predominantly White neighborhoods, highlighting the need for targeted tobacco reduction interventions.
Article Synopsis
- - White matter hyperintensities indicate damage in the brain's white matter, which can lead to brain shrinkage and is linked to dementia; a study of over 51,000 people found that larger volumes of these hyperintensities correspond to thinner brain cortex.
- - Researchers identified 20 significant genetic loci related to white matter hyperintensities that affect genes involved in brain cell types known to support vascular health and neuronal function; some of these genes play roles in processes like axonal structure and transport within the brain.
- - The genetic traits tied to white matter issues were linked to cardiovascular health, neurodegeneration markers, and poorer cognitive performance, with a polygenic risk score effectively predicting dementia risk in a separate large
Rationale And Objectives: Misregistration artifacts between the PET and attenuation correction CT (CTAC) exams can degrade image quality and cause diagnostic errors. Deep learning (DL)-warped elastic registration methods have been proposed to improve misregistration errors.
Materials And Methods: 30 patients undergoing routine oncologic examination (20 F-FDG PET/CT and 10 Cu-DOTATATE PET/CT) were retrospectively identified and compared using unmodified CTAC, and a DL-augmented spatial transformation CT attenuation map.