Publications by authors named "K G Zhdanova"

Antimicrobial photodynamic therapy (APDT) has received a great deal of attention due to its unique ability to kill all currently known classes of microorganisms. To date, infectious diseases caused by bacteria and viruses are one of the main sources of high mortality, mass epidemics and global pandemics among humans. Every year, the emergence of three to four previously unknown species of viruses dangerous to humans is recorded, totaling more than 2/3 of all newly discovered human pathogens.

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Photodynamic therapy (PDT) in oncology is characterized by low invasiveness, minimal side effects, and little tissue scarring. Increasing the selectivity of PDT agents toward a cellular target is a new approach intended to improve this method. This study is devoted to the design and synthesis of a new conjugate based on meso-arylporphyrin with a low-molecular-weight tyrosine kinase inhibitor, Erlotinib.

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This paper reports on the design and synthesis of new multifunctional porphyrin-based therapeutic agents for potential therapeutic and diagnostic applications. Zinc complexes of A3B-type -arylporphyrins containing OH- and COOH- groups were modified with chelating ligands based on 4'-(4-methylphenyl)-2,2':6',2″-terpyridine derivatives in high yields. Novel complexes with Gd(III), Fe(III) were obtained for these conjugates.

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This work is devoted to the search for new antiherpes simplex virus type 1 (HSV-1) drugs among synthetic tetrapyrroles and to an investigation of their antiviral properties under nonphotodynamic conditions. In this study, novel amphiphilic 5,10,15,20-tetrakis(4-(3-pyridyl--propanoyl)oxyphenyl)porphyrin tetrabromide (), 5,10,15,20-tetrakis(4-(6-pyridyl--hexanoyl)oxyphenyl)porphyrin tetrabromide () and known 5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphyrin tetraiodide () were synthesized, and their dark antiviral activity in vitro against HSV-1 was studied. The influence of porphyrin's nanosized delivery vehicles based on Pluronic F127 on anti-HSV-1 activity was estimated.

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Nonlinear microresonators are very desired for a wide variety of applications. Up-conversion processes responsible for the transformation of IR laser radiation into visible are intensity-dependent and thus rather sensitive to all involved effects, which can mask each other. In this work we study the phenomena that are the most important for possible lasing in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4 H-pyran dye spherical microresonators: the two-photon absorption and photobleaching.

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