Publications by authors named "K G Valente"
Article Synopsis
- - The objective of the study was to review how neonatal status epilepticus (SE) is defined and measured, focusing on literature available on seizure burden in newborns.
- - The review analyzed 44 studies that primarily included infants with conditions like hypoxic-ischemic encephalopathy, using continuous EEG (cEEG) for SE identification, and mostly defined SE via specific seizure durations.
- - Key findings revealed significant variability in definitions of neonatal SE, with a consistent trend showing that higher seizure burden was linked to worse outcomes in the 16 studies that explored this relationship.
This manuscript provides practical insights, tips, and lessons particularly valuable for early-career healthcare professionals new to using ketogenic diet therapy (KDT) in clinical practice. The review aims to be accessible, emphasizing actionable knowledge that can be directly applied in a clinical setting. The KDT for epilepsy includes not only the classic KDT but also the modified Atkins diet, the medium-chain triglyceride ketogenic diet, and the low glycemic index treatment.
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- Decreased activity of the SLC26A4 protein, critical for ear fluid balance, is linked to hearing loss.
- Researchers found that the μ2 subunit of the AP-2 complex plays a key role in controlling SLC26A4's presence at the cell membrane where it helps reabsorb endolymph in the inner ear.
- By blocking clathrin-mediated endocytosis, they showed that more SLC26A4 accumulates on cell surfaces, suggesting that the SLC26A4-μ2 interaction directly influences how much SLC26A4 is available where it’s needed.
Article Synopsis
- - The International League Against Epilepsy's (ILAE) Task Force created recommendations for diagnosing and treating anxiety and depression in kids with epilepsy after reviewing studies on screening measures and treatment effectiveness.
- - Key recommendations for diagnosis include universal screening, closer monitoring for high-risk children, and using multiple sources to assess symptoms while emphasizing the importance of recognizing symptoms for better treatment outcomes.
- - For treatment, individualized plans are advised, with monitoring for mild cases and referrals for more severe conditions, alongside the development of clinical care pathways and age-appropriate psychosocial interventions.
Objectives: This study aims to determine the current state of CDD diagnosis and epilepsy treatment in an upper-middle-income country.
Methods: Forty-seven families of the Brazilian CDD Association were invited to participate in an online survey to gather information about the diagnosis and treatment of epilepsy.
Results: Forty-three families (91.