[Histologic foundations for evaluation of the crushed wound of the cerebrum in the clinical course of cranio-cerebral trauma as an intracranial extensive process].

As a result of light optic and electron microscopic investigation of human cerebral cortex obtained intraoperatively from different zones of the crushed wound that resulted from severe craniocerebral trauma, morphological criteria (widened perivascular and pericellular spaces, per rexin and diapedase hemorrhages, microcysts oedema of neurons, gliocytes and nerve fibres) were established, which, jointly, form an objective focus for considering the crushed wound focus in the cerebrum as an intracranial extensive process and substantiate the indications for its intraoperative removal.

[Morphologic manifestations of brain edema during experimental stimulation of the hypothalamus].

By methods of neurohistology, electron microscopy and histochemistry magistral and pial arteries of brain, cerebral and cerebellar cortex as well as main nuclear structures of midbrain, afterbrain and oblongated marrow were studied in 39 experimental and 33 control rabbits in dosed effect of electric current exerted on hypothalamus through electrodes introduced stereotaxically into posterior hypothalamic field. Dynamics of intensity of luminescence and distribution density of adrenergic nerve structures in the arteries studied, swelling and vacuolization of endotheliocytes in cerebral arterioles and capillaries, destruction of mitochondria and lipid drops accumulation in them were demonstrated, plasmorrhages and diapedese hemorrhages were noted. Edematous changes combined with alterations of oxidation and protein metabolism enzymes activity were detected in neurons and gliocytes.

[Changes in the auditory area of the cerebral cortex with clinical and experimental actions on the hypothalamus].

Neurohistological, newchistochemical and ultrastructural analysis in pia mater and brain cortex auditory zone in tumors of hypothalamo-hypophyseal localization (12 patients) and dozaged experimental influence on hypothalamus (60 rabbits with 30 control and 30 experimental ones) allowed to establish and follow up morphofunctional and pathological changes. The former appeared previously in adrenergic nerve structures of pia mater and cortical vascular bed and neuroglia, the latter--in cortical neurons. The results obtained may be used in otoneurology and neurosurgery in elucidation certain syndromes genesis, acoustic ones included in patients with tumors of mentioned localisation, directly influencing hypothalamic area.