Implementing a migrant and refugee mentoring program through action research.

This article reports an implementation, through action research, of the mentoring of recently arrived refugee and migrant children in secondary school years 9 and 10. The mentoring, by education students, was in: English language skills; literacy skills for other subjects; and, planning pathways for further education. There was a very positive reaction to the program from the mentees, coordinating teachers, schools and mentors.

Dad taught me nothing about relationships and sexuality: how contemporary Australian fathers became sex ed dads.

This mixed methods study explored Australian fathers' views about relationships and sexuality education (RSE) and their role within it. In the article we examine contemporary fathers' engagement with discussing relationships and sexuality with their children, compared to their recollections of their own fathers' involvement. We draw on survey data from 612 diverse Australian fathers of children aged 3-12 years and interview data from 10 fathers.

Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer.

Genomic alterations in cancer cells result in vulnerabilities that clinicians can exploit using molecularly targeted drugs, guided by knowledge of the tumour genotype. However, the selective activity of these drugs exerts an evolutionary pressure on cancers that can result in the outgrowth of resistant clones. Use of rational drug combinations can overcome resistance to targeted drugs, but resistance may eventually develop to combinatorial therapies.

Evaluation of the solid phase competition ELISA for detecting antibodies against the six foot-and-mouth disease virus non-O serotypes.

The solid-phase competition ELISA (SPCE) has been evaluated in both screening and titration assay formats for detecting antibodies against foot-and-mouth disease virus (FMDV) for the six non-O serotypes A, C, SAT 1, SAT 2, SAT 3 and Asia 1. Cut-off values were determined as a percentage inhibition of 40 for the SAT serotypes and 50 for serotypes A, C and Asia 1, which gave rise to specificity values ranging from 99.41% to 99.

A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma.

Metastatic renal cell carcinoma (RCC) is a molecularly heterogeneous disease that is intrinsically resistant to chemotherapy and radiotherapy. Although therapies targeted to the molecules vascular endothelial growth factor and mammalian target of rapamycin have shown clinical effectiveness, their effects are variable and short-lived, underscoring the need for improved treatment strategies for RCC. Here, we used quantitative phosphoproteomics and immunohistochemical profiling of 346 RCC specimens and determined that Src kinase signaling is elevated in RCC cells that retain wild-type von Hippel-Lindau (VHL) protein expression.