[The selective accumulation of monoclonal antibodies in the lungs after cyclophosphane administration to rats].

The study has demonstrated the possibility to use cyclophosphamide as a model of "impairment" agent for lung tissue cells to provide access of monoclonal antibodies to nuclear antigen structures. Biodistribution of monoclonal antibodies to various intracellular antigens was studied on Wistar rats pretreated with various doses of cyclophosphamide. Accumulation of 2C5 antibodies to cell nuclei was found to be dependent on the dose of cyclophosphamide administered.

[The current status of the problem and the treatment possibilities in disseminated malignant neoplasms of the maxilla].

A study of the results of treatment of 170 patients makes a case for combined electrosurgical resection of the maxilla and local chemotherapy with deposited cytostatic drugs for localized malignant tumors of this site. No recurrences were detected within the first 12 months in 75.4% of patients and 52%--in control.

[Polymer-drug complexes in the treatment of extensive ovarian cancer].

The paper presents the results of intracavitary chemotherapy with deposited cytostatics of advanced ovarian cancer as well experimental, morphological, biochemical and pharmacological data. Intraabdominal introduction of microspheres filled with cyclophosphamide, 5-fluorouracil, doxorubicin can be a variant of drug therapy in multimodality treatment of ovarian cancer. Combination of intracavitary chemotherapy with a systemic one has the advantage of local and regional effect which is not inhibited by mediated action of the deposited cytostatics via the systemic blood flow.

[Diagnosis and treatment of pseudotumors of the abdominal cavity and retroperitoneal space].

The diagnosis and treatment of pseudotumors of the abdominal cavity and retroperitoneal space are discussed on the basis of 23 cases. It is pointed out that intraoperative morphological study is necessary for making a precise diagnosis. The use of the MK-14 antimicrobial glue improves the results of management of pseudotumors due to the creation of a depo of the antiseptic chlorhexidine in the abdominal cavity with simultaneous air-tightness of the wounds and hemostasis.