Outcomes of CD19 CAR T in Transformed Indolent Lymphoma Compared to De Novo Aggressive Large B-Cell Lymphoma.

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized treatment of aggressive large B-cell lymphoma (aLBCL). Patients with transformed indolent non-Hodgkin lymphoma (tiNHL) were included in key CAR trials, but outcomes of CAR for this distinct, historically high-risk group are poorly understood. We conducted a multicenter retrospective study of 1182 patients with aLBCL receiving standard-of-care CAR T between 2017 and 2022, including 338 (29%) with tiNHL.

Dr. Soumya Swaminathan: A Pioneer in Global Health and Equity.

Dr. Soumya Swaminathan, a renowned Indian physician and scientist, revolutionized medical practices through her significant contributions to tuberculosis and human immunodeficiency virus research, yielding a lasting impact on global health. As the former Chief Scientist of the World Health Organization, her committed approach to healthcare has been instrumental in linking scientific research and evidence to policy development.

Role of Image-Free Robotic-Assisted Technology in Enhancing Accuracy of Implant Sizing for Total Knee Arthroplasty.

Background The selection of properly sized implants is essential to achieve a well-balanced knee and favorable clinical outcomes following Total Knee Arthroplasty (TKA). There is limited evidence in the literature regarding the effectiveness of robotic-assisted technology (RA-TKA) without imaging in accurately predicting implant sizes. Our aim was to provide an evidence-based assessment of this technology's accuracy in selecting appropriate implant sizes during robotic-assisted, image-free TKA.

Analysis of 30-day hospital readmissions and related risk factors for COVID-19 patients with myocarditis hospitalized in the United States during 2020.

Background: Despite extensive research on COVID-19 and its association with myocarditis, limited data are available on readmission rates for this subset of patients. Thirty-day hospital readmission rate is an established quality metric that is associated with increased mortality and cost.

Methods: This retrospective analysis utilized the Nationwide Readmission Database for the year 2020 to evaluate 30-day hospital readmission rates, risk factors, and clinical outcomes among COVID-19 patients who presented with myocarditis at their index hospitalization.

Randomized Trial of Pulsatile and Nonpulsatile Flow in Cyanotic and Acyanotic Congenital Heart Surgery.

Background: The study objective was to determine the impact of cardiopulmonary bypass perfusion modalities on cerebral hemodynamics and clinical outcomes in congenital cardiac surgery patients stratified by acyanotic versus cyanotic heart disease.

Methods: A total of 159 pediatric (age <18 years) cardiac surgery patients were prospectively randomized to pulsatile or nonpulsatile cardiopulmonary bypass and stratified by type of congenital heart disease: acyanotic versus cyanotic. Intraoperative cerebral gaseous microemboli counts and middle cerebral artery pulsatility index were assessed.