Publications by authors named "K G Papadakis"
Article Synopsis
- - A significant challenge in treating pediatric T-cell acute lymphoblastic leukemia is predicting and tackling leukemia relapse in the central nervous system (CNS), where leukemia cells can hide and resist treatment.
- - Researchers found that intrusive leukemia cells change gene expression patterns, leading to enhanced cell survival, resistance to chemotherapy, and faster disease progression when infiltrating the CNS.
- - The study revealed that leukemia cells interact with human meningeal cells, causing epigenetic changes that might serve as potential biomarkers to identify CNS involvement and relapse in leukemia patients.
Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study.
Lancet Respir Med
April 2024
Background: Macitentan is beneficial for long-term treatment of pulmonary arterial hypertension. The microvasculopathy of chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension are similar.
Methods: The phase 2, double-blind, randomised, placebo-controlled MERIT-1 trial assessed macitentan in 80 patients with CTEPH adjudicated as inoperable.
Geospace plasma simulations have progressed toward more realistic descriptions of the solar wind-magnetosphere interaction from magnetohydrodynamic to hybrid ion-kinetic, such as the state-of-the-art Vlasiator model. Despite computational advances, electron scales have been out of reach in a global setting. eVlasiator, a novel Vlasiator submodule, shows for the first time how electromagnetic fields driven by global hybrid-ion kinetics influence electrons, resulting in kinetic signatures.
View Article and Find Full Text PDFBackground & Aims: Gluten ingestion in patients with celiac disease can lead to gastrointestinal symptoms and small intestinal mucosal injury.
Methods: This gluten challenge phase 2 trial was double blind and placebo controlled, and it assessed the efficacy and safety of a 1200-mg dose of IMGX003 in patients with celiac disease exposed to 2 g of gluten per day for 6 weeks. The change in the ratio of villus height to crypt depth was the primary endpoint.
Shock waves in collisionless plasmas are among the most efficient particle accelerators in space. Shock reformation is a process important to plasma heating and acceleration, but direct observations of reformation at quasi-parallel shocks have been lacking. Here, we investigate Earth's quasi-parallel bow shock with observations by the four Magnetospheric Multiscale spacecraft.
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