Compositionally Tuned Self-Activated Alkali Metal Vanadates for High Color Rendering White LEDs and IR Reflective Pigments.

Phosphor-converted white light-emitting diodes (pc-WLEDs) with a supreme color rendering index (CRI) remain challenging, particularly due to the limited accessibility of efficient cyan-green-emitting phosphors in the 480-520 nm emission range. Herein, a novel rare earth-free cyan-green-emitting Ta-substituted CsVO phosphor that exhibits a VO charge transfer enabled cyan-green emission band centered at ∼520 nm under the 370 nm near UV (n-UV) light is reported with an internal quantum efficiency of 93.9%.

Rational design of metabolically stable HDAC inhibitors: An overhaul of trifluoromethyl ketones.

Epigenetic regulation of gene expression using histone deacetylase (HDAC) inhibitors is a promising strategy for developing new anticancer agents. The most common HDAC inhibitors are hydroxamates, which, though highly potent, have limitations due to their poor pharmacokinetic properties and lack of isoform selectivity. Trifluoromethylketones (TFMK) developed as alternatives to hydroxamates are rapidly metabolized to inactive trifluoromethyl alcohols in vivo, which prevented their further development as potential drug candidates.

Ethanolic extract of seeds triggers yeast metacaspase-dependent apoptotic pathway mediated by mitochondrial dysfunction through enhanced production of calcium and reactive oxygen species (ROS) in .

 is a widespread disease-causing yeast affecting humankind, which leads to urinary tract, cutaneous and various lethal systemic infections. As this infection rate steadily increases, it is becoming a significant public health problem. Recently,  has received much attention from researchers due to its diverse pharmacological properties, including antimicrobial effects.

Aortic Involvement in Antineutrophil Cytoplasmic Antibodies Vasculitis, a Coincidence or a Real Association?

Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a type of small-vessel vasculitis. It is unusual for ANCA to involve aorta. However, multiple cases have been found where ANCA involved large vessels, particularly the aorta.