Publications by authors named "K G McGrath"
The extraordinary preservation of Cueva de Los Murciélagos (Albuñol, Spain) provides a unique opportunity to identify the materials and the techniques involved in archery during the Early Neolithic period. Arrows with preserved feathers, tied fibres, adhesive substance, and two probable bowstrings have been studied trough an unprecedented multi-proxy investigation, including microscopy and biomolecular methods, to unravel archery techniques. The study has identified the oldest known sinew bowstrings, the first evidence for the use of olive tree (Olea europaea) and reed (Phragmites sp.
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- Indigenous maize varieties from eastern North America have significantly influenced breeding programs, but their origins remain unclear.
- Paleogenomic studies trace maize's journey to this region, indicating multiple migrations from Mexico, especially towards the northern U.S., including a notable path from the Southwest.
- Analysis shows that ancient Ozark maize specimens exhibit a unique wx1 gene linked to starch metabolism, demonstrating how selective pressures shaped maize domestication and connecting these varieties to the Northern Flints, vital for today's commercial maize.
Article Synopsis
- * Researchers used human stem cell-derived heart cells to create cardiac spheroids and exposed them to patient plasma from years after pregnancy to assess how gestational hypertension (GH) and preeclampsia (PE) affect heart cell function and viability.
- * Results showed that both GH and PE increased heart cell contraction rates, with PE also boosting heart cell shortening, while GH reduced cell viability; a proteomic analysis revealed specific proteins linked to heart issues in both conditions.
Objective: Androgen insensitivity syndrome (AIS) due to androgen receptor (AR) mutations creates a spectrum of clinical presentations based on residual AR function with the mildest impairment creating mild AIS (MAIS) whose undefined molecular mechanism and subtle clinical features leave it less understood and underdiagnosed.
Design: In silico modeling and in vitro androgen bioassay of the mutated AR are used to identify its structural and physiological mechanism. Clinical features and responses to high-dose testosterone treatment of three cases of MAIS across a six-generation family pedigree are described.
Article Synopsis
- Medication adjustments for Parkinson's disease are based on patient feedback and clinicians' assessments of motor symptoms like bradykinesia and tremor.
- This study evaluates how consistently different clinicians assess upper limb motor function in Parkinson's patients during video recordings of standardized hand movements.
- Results show that initial agreement among clinicians was poor, especially for certain movements, but training improved their consistency in ratings significantly.