Synthesis, Characterization and Solution Chemistry of trans-Indazoliumtetrachlorobis(Indazole)Ruthenate(III), a New Anticancer Ruthenium Complex. IR, UV, NMR, HPLC Investigations and Antitumor Activity. Crystal Structures of trans-1-Methyl-Indazoliumtetrachlorobis-(1-Methylindazole)Ruthenate(III) and its Hydrolysis Product trans-Monoaquatrichlorobis-(1-Methylindazole)-Ruthenate(III).

Besides intensive studies into the synthesis of the complex trans-Hlnd[RuCl(4)(ind)(2)] (Ind = indazole) 1, which differs remarkably from the usual method for the complexes of the HL[RuCl(4)L(2)] - type, competitive products and hydrolysis of this species are described. Stability and pseudo-first-order rate constant under physiological conditions of complex 1 in comparison with the analogous imidazole complex trans-Hlm[RuCl(4)im(2)] (Im = imidaZole) ICR were examined by means of HPLC, UV and conductivity measurements (K(obs.)(1) = 1.