Publications by authors named "K G Krauter"
Article Synopsis
- Tobacco and alcohol use contribute significantly to global mortality rates, with heritability playing a key role in these behaviors.
- This study utilized genetic data from a diverse population of 3.4 million individuals, including 21% non-European ancestry, to identify genetic variants linked to tobacco and alcohol use.
- Findings showed that while increased genetic diversity improved the identification of genomic loci, polygenic risk scores were less effective across different ancestries, underscoring the need for larger and more diverse genetic datasets for better predictive outcomes.
Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms.
J Am Acad Child Adolesc Psychiatry
July 2022
Article Synopsis
- This study examined the genetic factors behind internalizing symptoms (like anxiety and depression) in children and adolescents through extensive genome-wide association studies (GWAS) across 22 groups, involving over 64,000 participants aged 3 to 18.
- The findings showed no significant genetic markers for overall internalizing symptoms, with low heritability rates, but highlighted that self-reported symptoms had the highest genetic influences and remained consistent from childhood to adolescence.
- The research established strong genetic links between childhood internalizing symptoms and various adult mental health issues, suggesting that understanding these genetic correlations could help explain the continuity and overlap of psychiatric problems from childhood to adulthood.
Article Synopsis
- Childhood aggressive behavior (AGG) is significantly heritable, with around 50% of its variation attributed to genetics, as shown in a study analyzing data from over 87,000 children aged 1.5 to 18 years; however, no genome-wide significant SNPs were identified.* -
- Three significant genes (ST3GAL3, PCDH7, and IPO13) linked to educational traits were found, and genetic analysis revealed moderate to strong correlations between AGG and various psychiatric traits, with notable weak correlations concerning teacher assessments.* -
- The research also showed negative genetic correlations of aggression with cognitive abilities and age at first birth, alongside strong correlations with smoking behaviors, highlighting complex genetic interactions within childhood aggression.*
Article Synopsis
- The study investigates the genetic basis of cannabis use disorder, revealing a strong heritable component (50-70%) and its association with negative mental health outcomes.
- A large-scale genome-wide association study (GWAS) was conducted using a significant sample size, identifying two important genetic loci linked to cannabis use disorder.
- Findings suggest that while there is a genetic correlation between cannabis use and cannabis use disorder, they are genetically distinct, with cannabis use disorder being linked to other psychiatric issues like ADHD, depression, and schizophrenia.
There is great interest in understanding the impact of rare variants in human diseases using large sequence datasets. In deep sequence datasets of >10,000 samples, ~10% of the variant sites are observed to be multi-allelic. Many of the multi-allelic variants have been shown to be functional and disease-relevant.
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