Publications by authors named "K G Koski"
Article Synopsis
- Single crystals of organic compounds that respond to heat or light are well-studied, but those showing extreme mechanical response are less common in research.
- A tetrafluoro(aryl)sulfanylated bicyclopentane developed in this study exhibited a low-temperature thermosalient effect, where crystals jumped and disintegrated at temperatures below ∼193 K.
- Investigations using various techniques revealed that the mechanical response is not solely due to a chemical transformation or phase transition, but rather related to the release of built-up strain and possibly influenced by microstructural changes or impurities within the crystal.
Brillouin Light Scattering (BLS) spectroscopy is a non-invasive, non-contact, label-free optical technique that can provide information on the mechanical properties of a material on the sub-micron scale. Over the last decade it has seen increased applications in the life sciences, driven by the observed significance of mechanical properties in biological processes, the realization of more sensitive BLS spectrometers and its extension to an imaging modality. As with other spectroscopic techniques, BLS measurements not only detect signals characteristic of the investigated sample, but also of the experimental apparatus, and can be significantly affected by measurement conditions.
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- - The study aims to investigate the lipid profiles in early 2nd trimester amniotic fluid of healthy normal-weight mothers who have either large-for-gestational age (LGA) or appropriate-for-gestational age (AGA) infants, while also examining the relationship between lipid profiles and insulin/glucose levels.
- - Researchers analyzed bio-banked amniotic fluid samples using advanced mass spectrometry techniques, comparing 15 LGA infants to 15 AGA infants and identified significant differences, including higher levels of specific phosphatidic acid species in LGA samples.
- - The results suggest that even in healthy normal-weight mothers, there are early signs of disrupted lipid metabolism when carrying LGA infants, with no correlation found
Human nucleotide exchange factors GRPEL1 and GRPEL2 play pivotal roles in the ADP-ATP exchange within the protein folding cycle of mitochondrial HSP70 (mtHSP70), a crucial chaperone facilitating protein import into the mitochondrial matrix. Studies in human cells and mice have indicated that while GRPEL1 serves as an essential co-chaperone for mtHSP70, GRPEL2 has a role regulated by stress. However, the precise structural and biochemical mechanisms underlying the distinct functions of the GRPEL proteins have remained elusive.
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- Intercalation of elements like Ag, Bi, In, and others into two-dimensional α-MoO alters its properties significantly, affecting aspects such as acoustic phonons and elastic constants.
- The intercalation impacts material characteristics including electronic bandgaps, color changes, and structural properties, leading to optical effects such as color transformation from transparent to blue or orange.
- The study reveals complex relationships between material properties, showing correlations between in-plane stiffness and bandgap changes, as well as varying Raman modes linked to other characteristics like shear modulus and preferred crystal structures.