Bone Marrow Stem Cell and Decellularized Human Amniotic Membrane for the Treatment of Nonhealing Wound After Radiation Therapy.

Objectives: In this study, our aim was to create a bioactive wound dressing that combined decellularized and lyophilized human amniotic membrane and freeze-dried rat bone marrow stem cells for the treatment of nonhealing wounds.

Materials And Methods: For the decellularized human amniotic membrane, sodium dodecyl sulfate and 1% Triton X-100 were used. The mononuclear fraction of bone marrow stem cells was isolated by density gradient centrifugation using Ficoll Paque Plus (GE Healthcare Bio-Sciences, Pittsburgh, PA, USA).

Antitumor and adjuvant effects of phagelysates of E.coli in mice with Ehrlich carcinoma.

Aim: To augment anti-tumor host response and overcome the tumor-induced immunosuppression is of paramount importance especially when patient is subjected to radio-/chemotherapy and immune system suffers significantly. Various immunological methods have been employed as supplemental antitumor therapies. We were aimed to investigate the antitumor potential of phagelysates of gram-negative bacteria and their adjuvant effects for conventional chemotherapy in experiment.

[Application of bacterial thermo- and phagelysates for suppression of malignant tumor growth in experimental studies: 2 comparative analysis of anticancer efficacy of thermo- and phagelysates of Ps. aeruginosa and E. coli].

In the presented work antitumor effects of thermo- and phagelysates of Ps.aeruginosa and E.coli on Ehrlich carcinoma growth in mice have been studied.

[Application of bacterial thermo-and phagelysates for suppression of malignant tumor growth in experimental studies: 1. Anticancer efficacy of thermo- and phagelysates of E.coli].

Immunotherapy is considered as one of the promising treatment strategies for patients with malignant tumors. In the presented work antitumor effects of E.coli thermo- and phagelysates on Ehrlich carcinoma growth in mice have been studied.

[New solution for cells and organs tissue conservation].

One of the major problems in organ and tissue transplantation is the conservation of donor's material from the moment of its impressments till its grafting in the recipient's organism. The new direction in transplantation is a method of liver tissue micro-fragments transplantation in bio-container Kakabadze, which was elaborated at the Department of Clinical Anatomy of Georgian State Medical Academy. In this work the results of investigation of hepatocytes' viability in micro-fragments were studied.